This is a competing renewal application of a cooperative agreement supporting the """"""""Chimpanzee Biomedical Research Resource"""""""" (CBRR) at the Michale E. Keeling Center for Comparative Medicine and Research (KCCMR) of The University of Texas MD Anderson Cancer Center in Bastrop, TX. The CBRR is a national research resource of 159 chimpanzees housed within the chimpanzee housing complex of the KCCMR. The CBRR is one of only four research resources in the world capable of conducting biomedical research in this species. Over the past 35 years, the CBRR has developed the highly specialized housing facilities, laboratories, management techniques and staff essential for maintaining chimpanzees and conducting research using this important model. The CBRR's primary objectives continue to focus on colony care and maintenance, provision of the infrastructure needed to conduct studies for investigators who need to access chimpanzees, and conducting studies to enhance the research value of chimpanzees. During the current funding period, we developed an informational website to help scientists assess the suitability of chimpanzees as relevant models for their studies and inform the public of the value of chimpanzees. We plan to continue to make available chimpanzee-derived cell lines, antibodies and other biological materials through the Chimpanzee Experimental Tools and Laboratory Reference Value Registry. The CBRR is organized into three functional cores that include the Resource Management Core, the Behavioral Management Core, and the Resource-related Research Core. Studies supported by the CBRR will continue to emphasize the characterization of the chimpanzee immune system and the numerous collaborative behavioral studies through the Behavioral Management Core. These include studies of the physiologic and immunologic consequences of research manipulations on chimpanzees trained to voluntarily cooperate with research procedures compared to untrained chimpanzees that must be anesthetized. The CBRR will continue to maintain its leadership role in the training of chimpanzees to voluntarily participate in research and clinical manipulations using positive reinforcement techniques. Beginning with this period of support, we plan to categorize all chimpanzees within the CBRR using the G-MARC as described in the RFA-RR-10-008. By expanding and improving the availability of CBRR resources, conducting resource-related research, and containing costs, the CBRR will continue to provide a critically important, highly specialized, research resource that addresses human health needs.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD011197-14
Application #
8731291
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Watson, Harold L
Project Start
2000-09-01
Project End
2016-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Veterinary Sciences
Type
Overall Medical
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77030
Vale, Gillian L; Davis, Sarah J; Lambeth, Susan P et al. (2017) Acquisition of a socially learned tool use sequence in chimpanzees: Implications for cumulative culture. Evol Hum Behav 38:635-644
Latzman, Robert D; Schapiro, Steven J; Hopkins, William D (2017) Triarchic Psychopathy Dimensions in Chimpanzees (Pan troglodytes): Investigating Associations with Genetic Variation in the Vasopressin Receptor 1A Gene. Front Neurosci 11:407
Hopkins, William D; Meguerditchian, Adrien; Coulon, Olivier et al. (2017) Motor skill for tool-use is associated with asymmetries in Broca's area and the motor hand area of the precentral gyrus in chimpanzees (Pan troglodytes). Behav Brain Res 318:71-81
Hopkins, William D; Coulon, Oliver; Meguerditchian, Adrien et al. (2017) Genetic Factors and Orofacial Motor Learning Selectively Influence Variability in Central Sulcus Morphology in Chimpanzees (Pan troglodytes). J Neurosci 37:5475-5483
Watson, Stuart K; Reamer, Lisa A; Mareno, Mary Catherine et al. (2017) Socially transmitted diffusion of a novel behavior from subordinate chimpanzees. Am J Primatol 79:
Vale, Gillian L; Davis, Sarah J; van de Waal, Erica et al. (2017) Lack of conformity to new local dietary preferences in migrating captive chimpanzees. Anim Behav 124:135-144
Nehete, Pramod N; Magden, Elizabeth R; Nehete, Bharti P et al. (2017) Age- and Sex-associated Differences in Phenotypic and Functional Characteristics of Peripheral Blood Lymphocytes in Chimpanzees (Pan troglodytes). J Am Assoc Lab Anim Sci 56:509-519
Latzman, Robert D; Patrick, Christopher J; Freeman, Hani J et al. (2017) Etiology of Triarchic Psychopathy Dimensions in Chimpanzees (Pan troglodytes). Clin Psychol Sci 5:341-354
Hopkins, William D; Hopkins, Anna M; Misiura, Maria et al. (2016) Sex differences in the relationship between planum temporale asymmetry and corpus callosum morphology in chimpanzees (Pan troglodytes): A combined MRI and DTI analysis. Neuropsychologia 93:325-334
Vale, Gill L; Flynn, Emma G; Pender, Lydia et al. (2016) Robust retention and transfer of tool construction techniques in chimpanzees (Pan troglodytes). J Comp Psychol 130:24-35

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