This is a competing renewal application of a cooperative agreement supporting the """"""""Chimpanzee Biomedical Research Resource"""""""" (CBRR) at the Michale E. Keeling Center for Comparative Medicine and Research (KCCMR) of The University of Texas MD Anderson Cancer Center in Bastrop, TX. The CBRR is a national research resource of 159 chimpanzees housed within the chimpanzee housing complex of the KCCMR. The CBRR is one of only four research resources in the world capable of conducting biomedical research in this species. Over the past 35 years, the CBRR has developed the highly specialized housing facilities, laboratories, management techniques and staff essential for maintaining chimpanzees and conducting research using this important model. The CBRR's primary objectives continue to focus on colony care and maintenance, provision of the infrastructure needed to conduct studies for investigators who need to access chimpanzees, and conducting studies to enhance the research value of chimpanzees. During the current funding period, we developed an informational website to help scientists assess the suitability of chimpanzees as relevant models for their studies and inform the public of the value of chimpanzees. We plan to continue to make available chimpanzee-derived cell lines, antibodies and other biological materials through the Chimpanzee Experimental Tools and Laboratory Reference Value Registry. The CBRR is organized into three functional cores that include the Resource Management Core, the Behavioral Management Core, and the Resource-related Research Core. Studies supported by the CBRR will continue to emphasize the characterization of the chimpanzee immune system and the numerous collaborative behavioral studies through the Behavioral Management Core. These include studies of the physiologic and immunologic consequences of research manipulations on chimpanzees trained to voluntarily cooperate with research procedures compared to untrained chimpanzees that must be anesthetized. The CBRR will continue to maintain its leadership role in the training of chimpanzees to voluntarily participate in research and clinical manipulations using positive reinforcement techniques. Beginning with this period of support, we plan to categorize all chimpanzees within the CBRR using the G-MARC as described in the RFA-RR-10-008. By expanding and improving the availability of CBRR resources, conducting resource-related research, and containing costs, the CBRR will continue to provide a critically important, highly specialized, research resource that addresses human health needs.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
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Special Emphasis Panel (ZRR1)
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Watson, Harold L
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University of Texas MD Anderson Cancer Center
Veterinary Sciences
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United States
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Davis, Sarah J; Vale, Gillian L; Schapiro, Steven J et al. (2016) Foundations of cumulative culture in apes: improved foraging efficiency through relinquishing and combining witnessed behaviours in chimpanzees (Pan troglodytes). Sci Rep 6:35953
Hopkins, William D; Hopkins, Anna M; Misiura, Maria et al. (2016) Sex differences in the relationship between planum temporale asymmetry and corpus callosum morphology in chimpanzees (Pan troglodytes): A combined MRI and DTI analysis. Neuropsychologia 93:325-334
Vale, Gill L; Flynn, Emma G; Pender, Lydia et al. (2016) Robust retention and transfer of tool construction techniques in chimpanzees (Pan troglodytes). J Comp Psychol 130:24-35
Claidière, Nicolas; Whiten, Andrew; Mareno, Mary C et al. (2015) Selective and contagious prosocial resource donation in capuchin monkeys, chimpanzees and humans. Sci Rep 5:7631
Brosnan, Sarah F; Hopper, Lydia M; Richey, Sean et al. (2015) Personality influences responses to inequity and contrast in chimpanzees. Anim Behav 101:75-87
Hopkins, William D; Reamer, Lisa; Mareno, Mary Catherine et al. (2015) Genetic basis in motor skill and hand preference for tool use in chimpanzees (Pan troglodytes). Proc Biol Sci 282:20141223
Leavens, David A; Reamer, Lisa A; Mareno, Mary Catherine et al. (2015) Distal Communication by Chimpanzees (Pan troglodytes): Evidence for Common Ground? Child Dev 86:1623-38
Gómez-Robles, Aida; Hopkins, William D; Schapiro, Steven J et al. (2015) Relaxed genetic control of cortical organization in human brains compared with chimpanzees. Proc Natl Acad Sci U S A 112:14799-804
Hopper, Lydia M; Lambeth, Susan P; Schapiro, Steven J et al. (2014) Social comparison mediates chimpanzees' responses to loss, not frustration. Anim Cogn 17:1303-11
Lou, Dianne I; McBee, Ross M; Le, Uyen Q et al. (2014) Rapid evolution of BRCA1 and BRCA2 in humans and other primates. BMC Evol Biol 14:155

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