A multi-spectral scanning fiber endoscope (SFE) will be developed to image the panel of fluorescent-labeled peptides developed in Project 2 that have specific binding activity to amplified and/or over expressed gene targets identified in Project 1. Image processing algorithms will be developed to stitch together individual images to form a panorama of the esophageal mucosal surface, and

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163059-02
Application #
8555332
Study Section
Special Emphasis Panel (ZCA1-SRLB-1 (O1))
Project Start
2011-09-21
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
2
Fiscal Year
2012
Total Cost
$228,673
Indirect Cost
$61,943
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zhou, Juan; He, Lei; Pang, Zhijun et al. (2017) Identification and validation of FGFR2 peptide for detection of early Barrett's neoplasia. Oncotarget 8:87095-87106
Savastano, Luis E; Seibel, Eric J (2017) Scanning Fiber Angioscopy: A Multimodal Intravascular Imaging Platform for Carotid Atherosclerosis. Neurosurgery 64:188-198
Savastano, Luis E; Zhou, Quan; Smith, Arlene et al. (2017) Multimodal laser-based angioscopy for structural, chemical and biological imaging of atherosclerosis. Nat Biomed Eng 1:
Zhou, Quan; Li, Zhao; Zhou, Juan et al. (2016) In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft. Photoacoustics 4:43-54
Joshi, Bishnu P; Wang, Thomas D (2016) Gastrointestinal imaging in 2015: Emerging trends in endoscopic imaging. Nat Rev Gastroenterol Hepatol 13:72-3
Ferrer-Torres, Daysha; Nancarrow, Derek J; Kuick, Rork et al. (2016) Genomic similarity between gastroesophageal junction and esophageal Barrett's adenocarcinomas. Oncotarget 7:54867-54882
Joshi, Bishnu P; Duan, Xiyu; Kwon, Richard S et al. (2016) Multimodal endoscope can quantify wide-field fluorescence detection of Barrett's neoplasia. Endoscopy 48:A1-A13
Joshi, Bishnu P; Zhou, Juan; Pant, Asha et al. (2016) Design and Synthesis of Near-Infrared Peptide for in Vivo Molecular Imaging of HER2. Bioconjug Chem 27:481-94
Sturm, Matthew B; Wang, Thomas D (2015) Emerging optical methods for surveillance of Barrett's oesophagus. Gut 64:1816-23
Jiang, Hui; Salzman, Julia (2015) A penalized likelihood approach for robust estimation of isoform expression. Stat Interface 8:437-445

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