Accurate and thorough curation of all of the data generated via PENTACON is a necessary ingredient of the glue that will bind the project together;sharing of pre-publication data amongst the consortium would be nearly impossible without such robust curation efforts. In addition, all data that flow into PENTACON and can be released under compliance rules will be publicly available to the greater research community. We will distribute data both through the PENTACON database, which will include sophisticated search and analysis tools that depend on the appropriate annotation and connection between data (see Databases and Integration Core), as well as all appropriate public repositories and/or model organism databases. Thus, the impact of this large collection of well-annotated data will go far beyond the consortium itself. While curation efforts in general are expensive endeavors, they are vital to the success of an enterprise as novel and as complex as we are proposing here. To limit the costs, our approach is to have a relatively lean but permanent staff of curators who will be responsible for overall monitoring of the process and several different more specific tasks. We will take a practical approach and curate to the extent necessary to meet the minimum requirements of PENTACON researchers (sufficient that these investigators from diverse disciplines can communicate in a common language) and the standards set by public repositories for a particular data type, rather than to an exhaustive ideal. For example, early in Year 1, we will survey the data modelers in PENTACON to determine exactly what they need to utilize metabolomics data. By annotating the information that the modelers require plus any additional information that is standard for publication of metabolomics data, we will have met any needs of the vast majority of researchers who want to use the data. We expect that our curation efforts on both PENTACON-generated and external data will have a significant impact on research. We will provide a rich, well-annotated source of a wide variety of data that will be able to be accessible to the scientific community at large to connect findings together in an important and scientifically rigorous manner.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HL117798-01
Application #
8126754
Study Section
Special Emphasis Panel (ZGM1-PPBC-0 (GL))
Project Start
2012-08-01
Project End
2017-05-31
Budget Start
2012-08-01
Budget End
2013-05-31
Support Year
1
Fiscal Year
2012
Total Cost
$311,359
Indirect Cost
$70,306
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Martin, Sarah A; Gijón, Miguel A; Voelker, Dennis R et al. (2014) Measurement of lysophospholipid acyltransferase activities using substrate competition. J Lipid Res 55:782-91
Keramati, Ali R; Fathzadeh, Mohsen; Go, Gwang-Woong et al. (2014) A form of the metabolic syndrome associated with mutations in DYRK1B. N Engl J Med 370:1909-19
Chakraborty, Raja; Bhullar, Rajinder P; Dakshinamurti, Shyamala et al. (2014) Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor. PLoS One 9:e85937
Zarini, Simona; Hankin, Joseph A; Murphy, Robert C et al. (2014) Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells. Prostaglandins Other Lipid Mediat 113-115:52-61
Obinata, Hideru; Gutkind, Sarah; Stitham, Jeremiah et al. (2014) Individual variation of human S1P? coding sequence leads to heterogeneity in receptor function and drug interactions. J Lipid Res 55:2665-75
Toung, Jonathan M; Lahens, Nicholas; Hogenesch, John B et al. (2014) Detection theory in identification of RNA-DNA sequence differences using RNA-sequencing. PLoS One 9:e112040
Jiang, Yan; Djuric, Zora; Sen, Ananda et al. (2014) Biomarkers for personalizing omega-3 fatty acid dosing. Cancer Prev Res (Phila) 7:1011-22
Tang, Wai Ho; Stitham, Jeremiah; Jin, Yu et al. (2014) Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets. Circulation 129:1598-609
Lu, Yi-Chien; Chang, Sung-Hee; Hafner, Markus et al. (2014) ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. Cell Rep 9:2330-43
O'Donnell, Valerie B; Murphy, Robert C; Watson, Steve P (2014) Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circ Res 114:1185-203

Showing the most recent 10 out of 19 publications