In response to the NIH Program Announcement PAR-13-279, Charles R. Drew University of Medicine and Science (CDU) proposes to continue and expand the success of the Accelerating excellence In Science (AXIS) program. AXIS is the integrated """"""""home"""""""" for clinical and translational research. AXIS houses experienced leadership as well as a myriad of clinical, translational, community-partnered activities, well matched by the education, training, and technology resources and excellent research core services. In the first five years, AXIS has laid the foundation at CDU to establish itself as the central hub of translational research. In the next five years, CDU will continue building on this progress and further develop its focus as the main research infrastructure program that will promote multi- and interdisciplinary collaborations between CDU investigators and community partners targeting health disparities. The vision of the University Research Enterprise is to be a leading player in the national effort to eliminate health disparities, specifically through AXIS in three areas of focus which disproportionally affect Service Planning Area 6: Cancer, Cardiometabolic Disease (CMD), and HIV/AIDS. AXIS proposes three programmatic goals that align with the vision of the University's Research Enterprise: """""""" Goal 1: To enhance the infrastructure capacity in translational research in the areas of Cancer, Cardiometabolic, and HIV/AIDS. Although other areas of research at CDU will also be served, the focus will be to create expertise and research success in these three areas.
This aim will also ensure that CDU continues to provide national leadership in reducing health disparities by increasing the quality and quantity of researchers from minority and underserved populations conducting disparities research. """"""""Goal 2: To integrate basic, clinical, and community-partnered translational research by fostering collaboration among disciplines, departments and schools at CDU, and collaboration with community leaders and investigators across other research institutions."""""""" Goal 3: To facilitate professional development and best practices in mentored clinical and translational research training on minority health and health disparities. """"""""To reach these goals, the AXIS Center will include 8 Cores that will offer services, resources, and training for all research conducted at CDU: 1 .Administrative Core, 2.Collaborations and Partnerships, and Community Core, 3.Professional Development and Pilots Core, 4. Evaluation Core, 5.Biomedical Informatics Core, 6.Research Design and Biostatistics Core, 7.Clinical Research Resources and Facilities Core, 8. Technology and Laboratory Core.
Development of a robust infrastructure for clinical and translational research to address high priority disease areas of cancer, cardiometabolic disorders, and HIV/AIDs will significantly impact health disparities among underserved and ethnic/racial minority populations.
|Madadi, Firooz; Madadi, Firoozeh; Maleki, Arash et al. (2016) A new method for tibial torsion measurement by computerized tomography. J Orthop 13:43-7|
|Bazargan, Mohsen; Yazdanshenas, Hamed; Han, Shelley et al. (2016) Inappropriate Medication Use Among Underserved Elderly African Americans. J Aging Health 28:118-38|
|Wu, Yanyuan; Sarkissyan, Marianna; Vadgama, Jaydutt V (2016) Epithelial-Mesenchymal Transition and Breast Cancer. J Clin Med 5:|
|Yazdanshenas, Hamed; Bazargan, Mohsen; Smith, James et al. (2016) Pain Treatment of Underserved Older African Americans. J Am Geriatr Soc 64:2116-2121|
|Yazdanshenas, Hamed; Washington 4th, Eleby R; Shamie, Arya Nick et al. (2016) Senior Managed Care System for Hip Fracture in the United States. Clin Orthop Surg 8:19-28|
|Schwartzman, Monica; Reginensi, Antoine; Wong, Jenny S et al. (2016) Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure. J Am Soc Nephrol 27:216-26|
|Harris, Kindred K; Zopey, Mohan; Friedman, Theodore C (2016) Metabolic effects of smoking cessation. Nat Rev Endocrinol 12:299-308|
|Gelfand, Robert; Vernet, Dolores; Bruhn, Kevin et al. (2016) Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features. Int J Oncol 48:2399-414|
|Del Pino, Homero E; Jones, Loretta; Forge, Nell et al. (2016) Integrating Community Expertise into the Academy: South Los Angeles' Community-Academic Model for Partnered Research. Prog Community Health Partnersh 10:329-38|
|Bazargan, Mohsen; Yazdanshenas, Hamed; Gordon, David et al. (2016) Pain in Community-Dwelling Elderly African Americans. J Aging Health 28:403-25|
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