Through the pilot component of the Autonomic RDCRC, the five institutions comprising this Consortium will collaborate in the choice and conduct of pilot projects, designed to take advantage of new clinical research opportunities in Rare Autonomic Disorders. As the investigators hear of promising new developments in the autonomic field, they will share these with their Consortium co-investigators. Upon discussion by teleconference or at one of the scheduled Consortium meetings.Jhe top management people from each institution may then propose to conduct a pilot study. The focus of a pilot study may be the development of a new assay or clinical instrument, or it could be an assessment of the therapeutic potential of a new medication.
The Autonomic RDCRC pilot studies may be used to generate feasibility data with promising clinical research potential. If pilot results are convincing, Consortium investigators may then recommend movement of the intervention from a pilot to a clinical trial.
|Singer, Wolfgang; Berini, Sarah E; Sandroni, Paola et al. (2017) Pure autonomic failure: Predictors of conversion to clinical CNS involvement. Neurology 88:1129-1136|
|Palma, Jose-Alberto; Spalink, Christy; Barnes, Erin P et al. (2017) Neurogenic dysphagia with undigested macaroni and megaesophagus in familial dysautonomia. Clin Auton Res :|
|Wallach, Asya I; Park, Hannah; Rucker, Janet C et al. (2017) Supranuclear gaze palsy and horizontal ocular oscillations in Creutzfeldt-Jakob disease. Neurology 89:749|
|Palma, Jose-Alberto; Norcliffe-Kaufmann, Lucy; Perez, Miguel A et al. (2017) Sudden Unexpected Death During Sleep in Familial Dysautonomia: A Case-Control Study. Sleep 40:|
|Coon, Elizabeth A; Low, Phillip A (2017) Pure autonomic failure without alpha-synuclein pathology: an evolving understanding of a heterogeneous disease. Clin Auton Res 27:67-68|
|Mendoza-Santiesteban, Carlos E; Palma, Jose-Alberto; Hedges 3rd, Thomas R et al. (2017) Pathological Confirmation of Optic Neuropathy in Familial Dysautonomia. J Neuropathol Exp Neurol 76:238-244|
|Kaufmann, Horacio; Jordan, Jens (2017) The Clinical Autonomic Research journal 2017 and onward. Clin Auton Res 27:1-2|
|Spalink, Christy L; Barnes, Erin; Palma, Jose-Alberto et al. (2017) Intranasal dexmedetomidine for adrenergic crisis in familial dysautonomia. Clin Auton Res 27:279-282|
|Bajaj, Sweta; Krismer, Florian; Palma, Jose-Alberto et al. (2017) Diffusion-weighted MRI distinguishes Parkinson disease from the parkinsonian variant of multiple system atrophy: A systematic review and meta-analysis. PLoS One 12:e0189897|
|Mendoza-Santiesteban, Carlos E; Palma, Jose-Alberto; Norcliffe-Kaufmann, Lucy et al. (2017) Familial dysautonomia: a disease with hidden tears. J Neurol 264:1290-1291|
Showing the most recent 10 out of 133 publications