This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The long-term goal of the Meharry Translational Research Center (MeTRC) is to establish a national model for clinical and translational health disparities research. MeTRC will synergize several ongoing research initiatives at Meharry supported by NCRR including Research Center in Minority Institutions, Center for AIDS Health Disparities Research, Center for Women's Health Research, Clinical Research Center, and Clinical Research Education and Career Development Program. Building on particular strengths of the research enterprise at Meharry, the focus of MeTRC will be on infectious disease, including HIV/AIDS, and women's health. An integrated program of translational research will be established that spans basic fundamental research to applied, participant-involved clinical studies. The short-term goal is to transform the capacity and infrastructure for translational research at Meharry.
The specific aims are: 1. Develop an administrative infrastructure that will facilitate development and maintenance of an integrated and innovative translational and clinical research program (MeTRC) 2. Develop a technical and support infrastructure that will sustain a program of integrated translational and clinical research. 3. Establish a process to facilitate the collaborative interactions and communication between RCTR faculty and staff needed to sustain and grow an integrated program of innovative clinical and translational research. 4. Establish a pipeline of basic, translational, and clinical research that will sustain and grow the MeTRC program. 5. Significantly enhance the infrastructure for translational and clinical research by establishing a new Participant and Clinical Interactions Resource (PCIR). 6. Develop a multidisciplinary training and career development program in clinical and translational research that takes advantage of the infrastructure, programs, and faculty of RCTR. 7. Engage and enhance an existing program created under the Vanderbilt-Meharry CTSA Focused Partnership to facilitate processes and partnerships in community-based clinical and translational research 8. Develop and implement a plan for self-evaluation of short-term and long-term RCTR goals including implementation and tracking of program activities.

Public Health Relevance

(provided by the applicant): The MeTRC environment will accelerate progress in the bench-to-bedside-to-community research enterprise, bi-directionally, as measured by peer-reviewed publications, increased internal and external collaborations including community partnerships, and improved health outcomes. Research activities will principally focus on infectious diseases in women including HIV/AIDS.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54RR026140-01
Application #
7961256
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2009-09-30
Project End
2010-06-30
Budget Start
2009-09-30
Budget End
2010-06-30
Support Year
1
Fiscal Year
2009
Total Cost
$1,386,000
Indirect Cost
Name
Meharry Medical College
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Dash, Sabyasachi; Balasubramaniam, Muthukumar; Dash, Chandravanu et al. (2018) Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs. J Vis Exp :
Dong, Xin-Hong; Ho, Meng-Hsuan; Liu, Bindong et al. (2018) Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. Sci Rep 8:8812
Balasubramaniam, Muthukumar; Pandhare, Jui; Dash, Chandravanu (2018) Are microRNAs Important Players in HIV-1 Infection? An Update. Viruses 10:
Welch, Jennifer L; Madison, Marisa N; Margolick, Joseph B et al. (2017) Effect of prolonged freezing of semen on exosome recovery and biologic activity. Sci Rep 7:45034
Morris, Matthew C; Kouros, Chrystyna D; Janecek, Kim et al. (2017) Community-level moderators of a school-based childhood sexual assault prevention program. Child Abuse Negl 63:295-306
Weems, Ebony; Singha, Ujjal K; Smith, Joseph T et al. (2017) The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei. Mol Biochem Parasitol 218:4-15
Dash, Sabyasachi; Balasubramaniam, Muthukumar; Rana, Tanu et al. (2017) Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b. eNeuro 4:
Balasubramaniam, Muthukumar; Davids, Benem; Addai, Amma B et al. (2017) Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes. J Vis Exp :
Uzhachenko, Roman; Shanker, Anil; Dupont, Geneviève (2016) Computational properties of mitochondria in T cell activation and fate. Open Biol 6:
Pulliam, Stephanie R; Pellom Jr, Samuel T; Shanker, Anil et al. (2016) Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine 84:74-87

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