To address the CTSA vision to have a sustained and transformative influence on the quality and value ofclinical & translational research, leadership from three academic institutions - Emory University, MorehouseSchool of Medicine, and Georgia Institute of Technology, along with other collaborative organizations formedin 2007, the Atlanta Clinical and Translational Science Institute (ACTSI). The ACTSI has integrateddiscovery, education, training and community engagement programs and engendered an unprecedentedlevel of transformation in clinical and translational research in our community. The ACTSI has developed anAtlanta 'home' for clinical and translational research through support of: 673 investigators, 520 projects, 93pilot projects in 96 research areas, over 193 federal (PHS) grants, 134 current or graduated MSCR, KL, orTL scholars, and over 75 additional active trainees. ACTSI support has also contributed to 661 scientificpublications, tripled inter-institutional collaborations, and led to important scientific breakthroughs in clinicaland translational science. Guided by the mission, '[tjhrough ethical community engagement, focusededucation and training, and innovative,support of discovery, the collaborative partners ofthe ACTSI rapidlyand efficiently translate scientific discoveries to impact all populations ofthe Atlanta community,' in the nextfive years, eleven key function prograrns will be charged with implementing three expanded specific aims.
Aim 1 : Promote discovery through inter-disciplinary collaboration, the development of novel and emergingtechnologies, drugs, devices, diagnostics and biologies, and the efficient translation of these discoveries tobenefit human health.
Aim 2 : Expand and improve outstanding programs to educate and train a growingcadre of ethnically diverse, clinician scientists, and increase the capacity and infrastructure to fostermultidisciplinary translational researchIteams.
Aim 3 : Actively engage the community in research that willengender the public trust in scientific discovery and the translation of new knowledge that ultimatelyenhances the health ofthe communities we serve.

Public Health Relevance

Created in tespohse to the NIH CTSA program, the Atlanta CTSI serves as acatalyst and incubator for clinical and ti'anslational research across Georgia and with regional and nationalimpact. The goals are to create and accelerate clinical and translational science discovery, buildinterdisciplinary research capacity, engage communities in health sciences activities, develop new researchtools and information technologies, and build the careers of clinical/translational scientists ofthe future.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
2UL1TR000454-06
Application #
8467214
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Rosenblum, Daniel
Project Start
2007-09-17
Project End
2017-05-31
Budget Start
2012-06-27
Budget End
2013-05-31
Support Year
6
Fiscal Year
2012
Total Cost
$5,378,765
Indirect Cost
$728,388
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Kempker, Russell R; Heinrichs, M Tobias; Nikolaishvili, Ketino et al. (2018) A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis. Eur Respir J 51:
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Zou, Li; Linck, Valerie; Zhai, Yu-Jia et al. (2018) Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport. J Biol Chem 293:1666-1675
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