To address the CTSA vision to have a sustained and transformative influence on the quality and value ofclinical & translational research, leadership from three academic institutions - Emory University, MorehouseSchool of Medicine, and Georgia Institute of Technology, along with other collaborative organizations formedin 2007, the Atlanta Clinical and Translational Science Institute (ACTSI). The ACTSI has integrateddiscovery, education, training and community engagement programs and engendered an unprecedentedlevel of transformation in clinical and translational research in our community. The ACTSI has developed anAtlanta 'home' for clinical and translational research through support of: 673 investigators, 520 projects, 93pilot projects in 96 research areas, over 193 federal (PHS) grants, 134 current or graduated MSCR, KL, orTL scholars, and over 75 additional active trainees. ACTSI support has also contributed to 661 scientificpublications, tripled inter-institutional collaborations, and led to important scientific breakthroughs in clinicaland translational science. Guided by the mission, '[tjhrough ethical community engagement, focusededucation and training, and innovative,support of discovery, the collaborative partners ofthe ACTSI rapidlyand efficiently translate scientific discoveries to impact all populations ofthe Atlanta community,' in the nextfive years, eleven key function prograrns will be charged with implementing three expanded specific aims.
Aim 1 : Promote discovery through inter-disciplinary collaboration, the development of novel and emergingtechnologies, drugs, devices, diagnostics and biologies, and the efficient translation of these discoveries tobenefit human health.
Aim 2 : Expand and improve outstanding programs to educate and train a growingcadre of ethnically diverse, clinician scientists, and increase the capacity and infrastructure to fostermultidisciplinary translational researchIteams.
Aim 3 : Actively engage the community in research that willengender the public trust in scientific discovery and the translation of new knowledge that ultimatelyenhances the health ofthe communities we serve.

Public Health Relevance

Created in tespohse to the NIH CTSA program, the Atlanta CTSI serves as acatalyst and incubator for clinical and ti'anslational research across Georgia and with regional and nationalimpact. The goals are to create and accelerate clinical and translational science discovery, buildinterdisciplinary research capacity, engage communities in health sciences activities, develop new researchtools and information technologies, and build the careers of clinical/translational scientists ofthe future.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
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Special Emphasis Panel (ZRR1-CR-1 (01))
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Rosenblum, Daniel
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Emory University
Internal Medicine/Medicine
Schools of Medicine
United States
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Nickel, Robert Sheppard; Qayed, Muna; Worthington-White, Diana et al. (2018) Infusion hemolysis after pediatric major ABO-mismatched bone marrow transplant: Comparison of two red blood cell depletion techniques. Pediatr Blood Cancer 65:
Kimura, Takayuki; Kobiyama, Kouji; Winkels, Holger et al. (2018) Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B. Circulation 138:1130-1143
Woodworth, Michael H; Kraft, Colleen S; Meredith, Erika J et al. (2018) Tacrolimus concentration to dose ratio in solid organ transplant patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection. Transpl Infect Dis 20:e12857
Grunwell, Jocelyn R; Travers, Curtis; Fitzpatrick, Anne M (2018) Inflammatory and Comorbid Features of Children Admitted to a PICU for Status Asthmaticus. Pediatr Crit Care Med 19:e585-e594
Baxi, S M; Greenblatt, R M; Bacchetti, P et al. (2018) Evaluating the association of single-nucleotide polymorphisms with tenofovir exposure in a diverse prospective cohort of women living with HIV. Pharmacogenomics J 18:245-250
Salindri, Argita D; Sales, Rose-Marie F; DiMiceli, Lauren et al. (2018) Isoniazid Monoresistance and Rate of Culture Conversion among Patients in the State of Georgia with Confirmed Tuberculosis, 2009-2014. Ann Am Thorac Soc 15:331-340
Kane, Andrea F; Bhatia, Anisha D; Denning, Patricia W et al. (2018) Routine Supplementation of Lactobacillus rhamnosus GG and Risk of Necrotizing Enterocolitis in Very Low Birth Weight Infants. J Pediatr 195:73-79.e2
Ghosh, Mimi; Daniels, Jason; Pyra, Maria et al. (2018) Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women. PLoS One 13:e0198412
Sil, Soumitri; Cohen, Lindsey L; Dampier, Carlton (2018) Pediatric pain screening identifies youth at risk of chronic pain in sickle cell disease. Pediatr Blood Cancer :e27538
Qayed, Muna; Wang, Tao; Hemmer, Michael T et al. (2018) Influence of Age on Acute and Chronic GVHD in Children Undergoing HLA-Identical Sibling Bone Marrow Transplantation for Acute Leukemia: Implications for Prophylaxis. Biol Blood Marrow Transplant 24:521-528

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