The principal performance objective of the Colorado Autoimmunity Center of Excellence (Colorado ACE) Administrative Core (Core A) is to facilitate the smooth operation of the Center, and establish an integrated and dynamic collaborative clinical research program that contributes significantly to the overall mission of the ACE consortium. This will be achieved by ensuring effective communication between its members, efficient fiscal and regulatory management, appropriate distribution of resources, timely preparation and submission of all reports, rapid implementation of new ideas and improved procedures, and by providing beneficial academic enrichment. The Core aims to promote and foster synergy and collaboration between the clinical and basic research programs both within the Center, and wider ACE Consortium, and to remove any barriers that could impede fulfillment of the core mission of the ACE program to accelerate the translation of research findings from the bench to the clinic. Activities that the Core will pursue/support will include: ' Formation of an Executive Committee drawn from key members of the Colorado ACE and other local experts in clinical, basic, and/or translational immunology that will meet quarterly to provide regular oversight and a forum for problem identification and resolution. ' Formation of an External Advisory Board that will meet annually to provide additional oversight, and also contribute to the establishment and maintenance of a strong collaborative environment that has both internal and external components. ' Provision of an interface between the Colorado ACE and the central Steering Committee of the ACE consortium, with the goal of achieving effective bi-directional communication of recommendations and ideas between the External Advisory Board, local Executive Committee, central Steering Committee and individual ACE members. ' Management of all regulatory and fiscal responsibilities related to the Center Grant. ' Provision of administrative support for Clinical Project Development ' Provision of academic enrichment for members of the Center. This will involve organization and support of seminars and journal clubs relevant to autoimmunity, and organization of an annual workshop devoted to Autoimmune Disease.

Public Health Relevance

The Colorado Autoimmunity Center of Excellence that this Core supports will develop and test innovative therapies for multiple autoimmune diseases; which together afflict up to 8% of the total US population. The Administrative Core will provide oversight and management of the Center and is essential to its functioning effectively.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Project with Complex Structure Cooperative Agreement (UM1)
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Special Emphasis Panel (ZAI1-PA-I)
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University of Colorado Denver
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Michels, Aaron W; Gottlieb, Peter A (2018) Learning From Past Failures of Oral Insulin Trials. Diabetes 67:1211-1215
Sparks, Jeffrey A; Iversen, Maura D; Yu, Zhi et al. (2018) Disclosure of Personalized Rheumatoid Arthritis Risk Using Genetics, Biomarkers, and Lifestyle Factors to Motivate Health Behavior Improvements: A Randomized Controlled Trial. Arthritis Care Res (Hoboken) 70:823-833
Ostrov, David A; Alkanani, Aimon; McDaniel, Kristen A et al. (2018) Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. J Clin Invest 128:1888-1902
Shimizu, Fumitaka; Schaller, Kristin L; Owens, Gregory P et al. (2017) Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica. Sci Transl Med 9:
Soltys, John N; Meyer, Stephanie A; Schumann, Hannah et al. (2017) Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED Nanoscopy. Biophys J 112:1692-1702
Vogel, Anna-Lena; Knier, Benjamin; Lammens, Katja et al. (2017) Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol 47:458-469
Liu, Yiting; Given, Katherine S; Harlow, Danielle E et al. (2017) Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathol Commun 5:25
Deane, Kevin D; Demoruelle, M Kristen; Kelmenson, Lindsay B et al. (2017) Genetic and environmental risk factors for rheumatoid arthritis. Best Pract Res Clin Rheumatol 31:3-18
Alberga, Domenico; Trisciuzzi, Daniela; Lattanzi, Gianluca et al. (2017) Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochim Biophys Acta Biomembr 1859:1326-1334
Bennett, Jeffrey L; Owens, Gregory P (2017) Neuromyelitis Optica: Deciphering a Complex Immune-Mediated Astrocytopathy. J Neuroophthalmol 37:291-299

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