The principal performance objective of the Colorado Autoimmunity Center of Excellence (Colorado ACE) Administrative Core (Core A) is to facilitate the smooth operation of the Center, and establish an integrated and dynamic collaborative clinical research program that contributes significantly to the overall mission of the ACE consortium. This will be achieved by ensuring effective communication between its members, efficient fiscal and regulatory management, appropriate distribution of resources, timely preparation and submission of all reports, rapid implementation of new ideas and improved procedures, and by providing beneficial academic enrichment. The Core aims to promote and foster synergy and collaboration between the clinical and basic research programs both within the Center, and wider ACE Consortium, and to remove any barriers that could impede fulfillment of the core mission of the ACE program to accelerate the translation of research findings from the bench to the clinic. Activities that the Core will pursue/support will include: ' Formation of an Executive Committee drawn from key members of the Colorado ACE and other local experts in clinical, basic, and/or translational immunology that will meet quarterly to provide regular oversight and a forum for problem identification and resolution. ' Formation of an External Advisory Board that will meet annually to provide additional oversight, and also contribute to the establishment and maintenance of a strong collaborative environment that has both internal and external components. ' Provision of an interface between the Colorado ACE and the central Steering Committee of the ACE consortium, with the goal of achieving effective bi-directional communication of recommendations and ideas between the External Advisory Board, local Executive Committee, central Steering Committee and individual ACE members. ' Management of all regulatory and fiscal responsibilities related to the Center Grant. ' Provision of administrative support for Clinical Project Development ' Provision of academic enrichment for members of the Center. This will involve organization and support of seminars and journal clubs relevant to autoimmunity, and organization of an annual workshop devoted to Autoimmune Disease.
The Colorado Autoimmunity Center of Excellence that this Core supports will develop and test innovative therapies for multiple autoimmune diseases; which together afflict up to 8% of the total US population. The Administrative Core will provide oversight and management of the Center and is essential to its functioning effectively.
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