of work: This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. The interaction of red cell generated oxidative with the DNA repair process is being investigated. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane. Animal and human studies are performed to investigate possible functional impairment associated with red cell damage.The interaction of amyloids with the erythrocyte is being investigated to determine whether the red cell plays a role in the transport of amyloids and in amyloid induced oxidative stress.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000047-43
Application #
8736477
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
43
Fiscal Year
2013
Total Cost
$460,225
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Mohanty, Joy G; Nagababu, Enika; Friedman, Jeffrey S et al. (2013) SOD2 deficiency in hematopoietic cells in mice results in reduced red blood cell deformability and increased heme degradation. Exp Hematol 41:316-21
Patel, Kushang V; Mohanty, Joy G; Kanapuru, Bindu et al. (2013) Association of the red cell distribution width with red blood cell deformability. Adv Exp Med Biol 765:211-6
Barodka, Viachaslau; Mohanty, Joy G; Mustafa, Asif K et al. (2013) Nitroprusside inhibits calcium-induced impairment of red blood cell deformability. Transfusion :
Gamaldo, Alyssa A; Ferrucci, Luigi; Rifkind, Joseph et al. (2013) Relationship between mean corpuscular volume and cognitive performance in older adults. J Am Geriatr Soc 61:84-9
Lucas, Heather R; Rifkind, Joseph M (2013) Considering the vascular hypothesis of Alzheimer's disease: effect of copper associated amyloid on red blood cells. Adv Exp Med Biol 765:131-8
Rifkind, Joseph M; Nagababu, Enika (2013) Hemoglobin redox reactions and red blood cell aging. Antioxid Redox Signal 18:2274-83
Nagababu, Enika; Usatyuk, Peter V; Enika, Divya et al. (2009) Vascular endothelial barrier dysfunction mediated by amyloid-beta proteins. J Alzheimers Dis 17:845-54
Mohanty, Joy G; Eckley, D Mark; Williamson, J D et al. (2008) Do red blood cell-beta-amyloid interactions alter oxygen delivery in Alzheimer's disease? Adv Exp Med Biol 614:29-35
Nagababu, Enika; Fabry, Mary E; Nagel, Ronald L et al. (2008) Heme degradation and oxidative stress in murine models for hemoglobinopathies: thalassemia, sickle cell disease and hemoglobin C disease. Blood Cells Mol Dis 41:60-6
Nagababu, Enika; Gulyani, Seema; Earley, Christopher J et al. (2008) Iron-deficiency anaemia enhances red blood cell oxidative stress. Free Radic Res 42:824-9

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