Abstract

of work: This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane. Animal and human studies are performed to investigate possible functional impairment associated with red cell damage.The interaction of amyloids with the erythrocyte is being investigated to determine whether the red cell plays a role in the transport of amyloids and in amyloid induced oxidative stress.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000047-39
Application #
7963863
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
39
Fiscal Year
2009
Total Cost
$345,957
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Rajadas, Jayakumar; Sun, Wenchao; Li, Hai et al. (2013) Enhanced A?(1-40) production in endothelial cells stimulated with fibrillar A?(1-42). PLoS One 8:e58194
Barodka, Viachaslau; Mohanty, Joy G; Mustafa, Asif K et al. (2013) Nitroprusside inhibits calcium-induced impairment of red blood cell deformability. Transfusion :
Gamaldo, Alyssa A; Ferrucci, Luigi; Rifkind, Joseph et al. (2013) Relationship between mean corpuscular volume and cognitive performance in older adults. J Am Geriatr Soc 61:84-9
Lucas, Heather R; Rifkind, Joseph M (2013) Considering the vascular hypothesis of Alzheimer's disease: effect of copper associated amyloid on red blood cells. Adv Exp Med Biol 765:131-138
Huertas, Alice; Das, Shonit R; Emin, Memet et al. (2013) Erythrocytes induce proinflammatory endothelial activation in hypoxia. Am J Respir Cell Mol Biol 48:78-86
Rifkind, Joseph M; Nagababu, Enika (2013) Hemoglobin redox reactions and red blood cell aging. Antioxid Redox Signal 18:2274-83
Nagababu, E; Mohanty, J G; Friedman, J S et al. (2013) Role of peroxiredoxin-2 in protecting RBCs from hydrogen peroxide-induced oxidative stress. Free Radic Res 47:164-71
Mohanty, Joy G; Nagababu, Enika; Friedman, Jeffrey S et al. (2013) SOD2 deficiency in hematopoietic cells in mice results in reduced red blood cell deformability and increased heme degradation. Exp Hematol 41:316-21
Patel, Kushang V; Mohanty, Joy G; Kanapuru, Bindu et al. (2013) Association of the red cell distribution width with red blood cell deformability. Adv Exp Med Biol 765:211-6
Rifkind, Joseph M; Salgado, Maria T; Cao, Zeling (2012) Regulation of oxygen delivery by the reaction of nitrite with RBCs under hypoxic conditions. Adv Exp Med Biol 737:183-9

Showing the most recent 10 out of 23 publications