During fiscal year 2009 we accomplished the following: 1. Completed protein and RNA analysis on 15 additional BLSA samples. CD4+ T cells were purified from peripheral blood mononuclear cells by positive selection and activated in vitro with anti-CD3 antibodies. Nuclear and cytoplasmic extracts were prepared for immunoblotting studies, and RNA prepared for microarray analyses. 2. Initiated analysis on samples from Elite-aging category. 3. Initiated proteomic studies on cytosolic and nuclear extracts to evaluate the best way to compare between BLSA samples.
| Bektas, Arsun; Schurman, Shepherd H; Sen, Ranjan et al. (2017) Human T cell immunosenescence and inflammation in aging. J Leukoc Biol : |
| Bektas, Arsun; Sen, Ranjan; Ferrucci, Luigi (2016) Does a bit of alcohol turn off inflammation and improve health? Age Ageing : |
| Bektas, Arsun; Zhang, Yongqing; Lehmann, Elin et al. (2014) Age-associated changes in basal NF-?B function in human CD4+ T lymphocytes via dysregulation of PI3 kinase. Aging (Albany NY) 6:957-74 |
| Bektas, Arsun; Zhang, Yongqing; Wood 3rd, William H et al. (2013) Age-associated alterations in inducible gene transcription in human CD4+ T lymphocytes. Aging (Albany NY) 5:18-36 |
| Munk, Rachel B; Sugiyama, Katsuki; Ghosh, Paritosh et al. (2011) Antigen-independent IFN-? production by human naïve CD4 T cells activated by IL-12 plus IL-18. PLoS One 6:e18553 |
| Kaileh, Mary; Sen, Ranjan (2010) Role of NF-kappaB in the anti-inflammatory effects of tocotrienols. J Am Coll Nutr 29:334S-339S |
