Abstract

The primary effort within the past year has centered on using novel genetic approaches to understand the basis of Alzheimer's disease. We have used high density SNP genotyping in an attempt to identify regions that may contain recessive mutations or risk factors causing or contributing to disease. This has involved analysis of individual families in addition to work on larger cohorts. In addition we have contributed toward the most recently published genome wide association study in Alzheimer's disease that describes CLU and PICALM variants as significant risk loci for Alzheimer's disease. Following this finding much of our work has centered on characterizing the extent of genetic variability at the CLU and PICALM loci, across different Alzheimer's disease populations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000950-09
Application #
8148361
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2010
Total Cost
$498,853
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Sassi, Celeste; Nalls, Michael A; Ridge, Perry G et al. (2018) Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiol Aging 66:179.e17-179.e29
Sargent, Lana; Nalls, Mike; Starkweather, Angela et al. (2018) Shared biological pathways for frailty and cognitive impairment: A systematic review. Ageing Res Rev 47:149-158
Ridge, Perry G; Karch, Celeste M; Hsu, Simon et al. (2018) Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Med 10:4
Chaudhury, Sultan; Patel, Tulsi; Barber, Imelda S et al. (2018) Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease. Neurobiol Aging 62:244.e1-244.e8
Barber, Imelda S; Braae, Anne; Clement, Naomi et al. (2017) Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array. Neurobiol Aging 49:215.e1-215.e8
Patel, T; Brookes, K J; Turton, J et al. (2017) Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease. Neuropathol Appl Neurobiol :
Mapstone, Mark; Lin, Feng; Nalls, Mike A et al. (2017) What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging 51:148-155
Barber, Imelda S; García-Cárdenas, Jennyfer M; Sakdapanichkul, Chidchanok et al. (2016) Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease. Neurobiol Aging 39:220.e1-7
Sassi, Celeste; Ridge, Perry G; Nalls, Michael A et al. (2016) Influence of Coding Variability in APP-A? Metabolism Genes in Sporadic Alzheimer's Disease. PLoS One 11:e0150079
Sassi, Celeste; Nalls, Michael A; Ridge, Perry G et al. (2016) ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiol Aging 46:235.e1-9

Showing the most recent 10 out of 45 publications