The primary goal of this proposal is to provide the applicant with expertise in the basic physical and computer sciences, neuroimaging methodology, and developmental psychopathology necessary to conduct cutting-edge research using functional magnetic resonance imaging (fMRI) based techniques so that he can develop an independent research career. Specifically, the proposal will initially provide an opportunity to train with and work under the supervision of a multidisciplinary team of consultants on two projects related to ADHD that will use fMRI to study: I) atomoxetine and methylphenidate treatment effects on frontostriatal activation in children with ADHD;and II) brain activation gradients related to persistence of ADHD in adolescence. The multidisciplinary team of consultants will ensure training in the wide variety disciplines that are incorporated in functional neuroimaging research. The various projects that form the research component of this proposal will also provide the applicant with the opportunity to work with other pre-eminent researchers who are consultants on these projects. The training and data generated by the research component of this proposal will inform and hopefully generate the pilot data of future research projects by the applicant that will eventually lead to an independent research career. The development of an independent research career that integrates approaches from developmental psychopathology, basic and behavioral neurosciences, and neuroimaging in the study of ADHD and other developmental disorders is the expected outcome of this award.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research & Training (K01)
Project #
Application #
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Wagner, Ann
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Icahn School of Medicine at Mount Sinai
Schools of Medicine
New York
United States
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Schulz, Kurt P; Li, Xiaobo; Clerkin, Suzanne M et al. (2017) Prefrontal and parietal correlates of cognitive control related to the adult outcome of attention-deficit/hyperactivity disorder diagnosed in childhood. Cortex 90:1-11
Schulz, Kurt P; Clerkin, Suzanne M; Newcorn, Jeffrey H et al. (2014) Guanfacine modulates the emotional biasing of amygdala-prefrontal connectivity for cognitive control. Eur Neuropsychopharmacol 24:1444-53
Schulz, Kurt P; Clerkin, Suzanne M; Fan, Jin et al. (2013) Guanfacine modulates the influence of emotional cues on prefrontal cortex activation for cognitive control. Psychopharmacology (Berl) 226:261-71
Clerkin, Suzanne M; Schulz, Kurt P; Berwid, Olga G et al. (2013) Thalamo-cortical activation and connectivity during response preparation in adults with persistent and remitted ADHD. Am J Psychiatry 170:1011-9
Schulz, Kurt P; Bedard, Anne-Claude V; Czarnecki, Rosa et al. (2011) Preparatory activity and connectivity in dorsal anterior cingulate cortex for cognitive control. Neuroimage 57:242-50
Bedard, Anne-Claude; Schulz, Kurt P; Cook Jr, Edwin H et al. (2010) Dopamine transporter gene variation modulates activation of striatum in youth with ADHD. Neuroimage 53:935-42
Schulz, Kurt P; Clerkin, Suzanne M; Halperin, Jeffrey M et al. (2009) Dissociable neural effects of stimulus valence and preceding context during the inhibition of responses to emotional faces. Hum Brain Mapp 30:2821-33
Solanto, Mary V; Schulz, Kurt P; Fan, Jin et al. (2009) Event-related FMRI of inhibitory control in the predominantly inattentive and combined subtypes of ADHD. J Neuroimaging 19:205-12
Clerkin, Suzanne M; Schulz, Kurt P; Halperin, Jeffrey M et al. (2009) Guanfacine potentiates the activation of prefrontal cortex evoked by warning signals. Biol Psychiatry 66:307-12
Schulz, Kurt P; Fan, Jin; Magidina, Olga et al. (2007) Does the emotional go/no-go task really measure behavioral inhibition? Convergence with measures on a non-emotional analog. Arch Clin Neuropsychol 22:151-60

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