The Reykjavik Study ascertained headache and migraine when subjects were middle-age. In a follow-up of mortality in the cohort, we found that migraineurs with aura were at increased risk of all cause mortality (adjusted (for sex and multivariables) hazard ratio 1.21, 95% confidence interval 1.12 to 1.30) and mortality from cardiovascular disease (1.27, 1.13 to 1.43) compared with people with no headache, while those with migraine without aura and non-migraine headache were not. Further examination of mortality from cardiovascular disease shows that people with migraine with aura were at increased risk of mortality from coronary heart disease (1.28, 1.11 to 1.49) and stroke (1.40, 1.10 to 1.78). In the same subjects, who are participating in in the follow-up Age Gene/Environment Susceptibilfity -Reykjavik Study (AGES-RS), we found After adjusting for age, sex, and follow-up time, compared with those not reporting headaches once or more per month (n = 3243), those with midlife migraine with aura (n = 361) had an increased risk of late-life infarct-like lesions (adjusted odds ratio OR, 1.4;95% confidence interval CI, 1.1-1.8) that specifically reflected an association with cerebellar lesions in women. In addition to these findings, several new loci were identified in consortia that incorporated two studies that are a part of the Neuroepidemiology portfolio: AGES-RS and GEM Study (the Netherlands)

National Institute of Health (NIH)
National Institute on Aging (NIA)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Institute on Aging
Zip Code
Kruit, Mark C; Thijs, Roland D; Ferrari, Michel D et al. (2013) Syncope and orthostatic intolerance increase risk of brain lesions in migraineurs and controls. Neurology 80:1958-65
Scher, Ann I; Eiriksdottir, Gudny; Garcia, Melissa et al. (2013) Lack of association between the MTHFR C677T variant and migraine with aura in an older population: could selective survival play a role? Cephalalgia 33:308-15
Roecklein, Kathryn A; Scher, Ann I; Smith, Albert et al. (2013) Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura. Cephalalgia 33:469-82
Gudmundsson, Larus S; Scher, Ann I; Sigurdsson, Sigurdur et al. (2013) Migraine, depression, and brain volume: the AGES-Reykjavik Study. Neurology 80:2138-44
Chasman, Daniel I; Schürks, Markus; Anttila, Verneri et al. (2011) Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 43:695-8
Ligthart, Lannie; de Vries, Boukje; Smith, Albert V et al. (2011) Meta-analysis of genome-wide association for migraine in six population-based European cohorts. Eur J Hum Genet 19:901-7
Gudmundsson, Larus S; Scher, Ann I; Aspelund, Thor et al. (2010) Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. BMJ 341:c3966
Scher, Ann I; Launer, Lenore J (2010) Migraine: migraine with aura increases the risk of stroke. Nat Rev Neurol 6:128-9