A major part of our work has been studying the cellular basis of pain sensation. Initially, we have concentrated on trigeminal and dorsal root ganglion neurons expressing the TRP-ion channels. We have been using a variety of pharmocological and molecular genetic techniques to explore the molecular architecture of these neurons and their sensitivity to drugs and other stimuli. In this reporting period we have shown that molecularly defined subsets of these cells are involved in different aspects of nociception. These neurons are also involved in detection of other classes of stimuli and we have determined they have plastic changes in their structure. Screens of molecules expressed in soamtosensory neurons have revealed a number of novel signaling molecules and at present we are studying their physiological role. In addition we have embarked on projects aimed at determining the molecular expression patterns of touch sensitive neurons.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2011
Total Cost
$1,003,228
Indirect Cost
Name
National Institute of Dental & Craniofacial Research
Department
Type
DUNS #
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Ran, Chen; Hoon, Mark A; Chen, Xiaoke (2016) The coding of cutaneous temperature in the spinal cord. Nat Neurosci 19:1201-9
Hoon, Mark A (2015) Molecular dissection of itch. Curr Opin Neurobiol 34:61-6
Mishra, Santosh K; Hoon, Mark A (2015) Transmission of pruriceptive signals. Handb Exp Pharmacol 226:151-62
Tränkner, Dimitri; Hahne, Nadeau; Sugino, Ken et al. (2014) Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways. Proc Natl Acad Sci U S A 111:11515-20
Bautista, Diana M; Wilson, Sarah R; Hoon, Mark A (2014) Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci 17:175-82
Goswami, Samridhi C; Mishra, Santosh K; Maric, Dragan et al. (2014) Molecular signatures of mouse TRPV1-lineage neurons revealed by RNA-Seq transcriptome analysis. J Pain 15:1338-59
Goswami, Samridhi C; Thierry-Mieg, Danielle; Thierry-Mieg, Jean et al. (2014) Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. Mol Pain 10:44
Mishra, Santosh K; Hoon, Mark A (2013) The cells and circuitry for itch responses in mice. Science 340:968-71
Pogorzala, Leah A; Mishra, Santosh K; Hoon, Mark A (2013) The cellular code for mammalian thermosensation. J Neurosci 33:5533-41
Kaszas, Krisztian; Keller, Jason M; Coddou, Claudio et al. (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther 340:152-60

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