1) We are continuing our work on exosomes as a source of biomarkers, including proteins and miRNA. 2) We are continuing a public-private consortium with the HESI Genomics microRNA Focus Group to compare standard protocol vs site-specific protocols from multiple sites;variations will identify which preanalytical steps affect microRNA detection and quantification in biofluids in drug-induced injury models. The initial model is a cardiotoxin that stimulates release of miRNAs into the circulation, which will shed light on renal handling of miRNA. Urinary miRNA from non-renal sources is expected to be non-exosomal. 3) We continue to work on alternatives to serum creatinine as surrogates for glomuerular filtration rate, such as serum cystatin C.
| Bavendam, Tamara G; Norton, Jenna M; Kirkali, Ziya et al. (2016) Advancing a Comprehensive Approach to the Study of Lower Urinary Tract Symptoms. J Urol 196:1342-1349 |
| Koritzinsky, E H; Street, J M; Star, R A et al. (2016) Quantification of Exosomes. J Cell Physiol : |
| Askenazi, David J; Morgan, Catherine; Goldstein, Stuart L et al. (2016) Strategies to improve the understanding of long-term renal consequences after neonatal acute kidney injury. Pediatr Res 79:502-8 |
| Qian, Chunqi; Yu, Xin; Pothayee, Nikorn et al. (2014) Live nephron imaging by MRI. Am J Physiol Renal Physiol 307:F1162-8 |
| Street, Jonathan M; Souza, Ana Carolina P; Alvarez-Prats, Alejandro et al. (2014) Automated quantification of renal fibrosis with Sirius Red and polarization contrast microscopy. Physiol Rep 2: |
| Street, Jonathan M; Yuen, Peter S T; Star, Robert A (2014) Bioactive exosomes: possibilities for diagnosis and management of bladder cancer. J Urol 192:297-8 |
| Leelahavanichkul, Asada; Souza, Ana Carolina P; Street, Jonathan M et al. (2014) Comparison of serum creatinine and serum cystatin C as biomarkers to detect sepsis-induced acute kidney injury and to predict mortality in CD-1 mice. Am J Physiol Renal Physiol 307:F939-48 |
| Zafrani, Lara; Ince, Can; Yuen, Peter S T (2013) Microparticles during sepsis: target, canary or cure? Intensive Care Med 39:1854-6 |
| Zhou, Hua; Kajiyama, Hiroshi; Tsuji, Takayuki et al. (2013) Urinary exosomal Wilms' tumor-1 as a potential biomarker for podocyte injury. Am J Physiol Renal Physiol 305:F553-9 |
| Molitoris, Bruce A; Okusa, Mark D; Palevsky, Paul M et al. (2012) Designing clinical trials in acute kidney injury. Clin J Am Soc Nephrol 7:842-3 |
Showing the most recent 10 out of 19 publications
