Cell Signaling of Host Defense

Fessler, Michael B.

Abstract

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its eleventh year at the NIEHS since inception. Publications since the last annual report include: 1. an invited review article on the potential for drugs targeting Liver X Receptor for treatment of inflammatory diseases in humans (Pubmed ID 28720427) 2. a collaborative workshop report through the American Thoracic Society on the effects of obesity on lung disease (Pubmed 28570148) 3. a collaborative paper on the role of TAK1 kinase in macrophage development (Pubmed ID 28182011) 4. a senior author publication on the role the stress response gene TNFAIP8 in human cancer (Pubmed ID 27834950) 5. a review article on pulmonary surfactant lipids in inflammatory disease (Pubmed ID 27286794) 6. a collaborative paper on the effect of ozone on Liver X Receptor in disease (Pubmed ID 27703007) 7. a collaborative paper on a novel chemical crosslinker for proteomics studies (Pubmed ID 27649375) 8. an invited review article on the role of cellular cholesterol in immunity (Pubmed ID 27692616) Additional accomplishments since our last report include an award to Dr. Fessler for being a Top Reviewer of the American Journal of Respiratory Cell and Molecular Biology, an invited international presentation by Dr. Fessler at the Transatlantic Airway Conference in Lucerne, Switzerland, and an invited presentation by Dr. Fessler at the NIH Inflammatory Disease Interest Group Seminar Series in Bethesda, MD.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAES102005-12
• Application #: 9550126
• Support Year: 12
• Fiscal Year: 2017

Institution

• Name: U.S. National Inst of Environ Hlth Scis

Publications

Kamal, Abu Hena M; Fessler, Michael B; Chowdhury, Saiful M (2018) Comparative and network-based proteomic analysis of low dose ethanol- and lipopolysaccharide-induced macrophages. PLoS One 13:e0193104

Fessler, Michael B (2018) The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease. Pharmacol Ther 181:1-12

Kumar, Ashutosh; Triquigneaux, Mathilde; Madenspacher, Jennifer et al. (2018) Sulfite-induced protein radical formation in LPS aerosol-challenged mice: Implications for sulfite sensitivity in human lung disease. Redox Biol 15:327-334

Fessler, Michael B (2017) A New Frontier in Immunometabolism. Cholesterol in Lung Health and Disease. Ann Am Thorac Soc 14:S399-S405

Fessler, Michael B (2017) CO2 as a Potential Obesogen: A Gas That Will Stick to Your Ribs. Am J Respir Cell Mol Biol 57:499-500

Sakamachi, Yosuke; Morioka, Sho; Mihaly, September R et al. (2017) TAK1 regulates resident macrophages by protecting lysosomal integrity. Cell Death Dis 8:e2598

Suratt, Benjamin T; Ubags, Niki D J; Rastogi, Deepa et al. (2017) An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc 14:1050-1059

Henderson, Michael W; Madenspacher, Jennifer H; Whitehead, Gregory S et al. (2017) Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice. Environ Health Perspect 125:097024

Azzam, Kathleen M; Madenspacher, Jennifer H; Cain, Derek W et al. (2017) Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces. JCI Insight 2:

Gabor, Kristin A; Fessler, Michael B (2017) Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense. Curr Mol Pharmacol 10:27-45