The major analyses of the NCS-R data set during this past year focus on comparisons between adolescent and adult patterns of psychopathology, particularly mania, major depression and anxiety disorders. We published a paper that compares patterns of depressive symptoms and correlates in adults and youth that demonstrates similar symptomatic structure but greater complexity in the adults, as expected. The subtypes identified in these analyses suggest that both symptom patterns and severity of depressive symptoms are sources of heterogeneity in major depressive disorder. We have also shown that patterns of mania in adults and youth are remarkably similar. Public Health Impact: These findings have provided novel knowledge on comparability of the structure of major depressive disorder in adults and adolescents. The central importance of symptoms that are somatic in quality (such as changes in appetite, weight, sleep and fatigue) in discriminating depressive subtypes has major implications for our understanding of the biologic pathways, treatment and opportunities for prevention of the consequences of this major public health problem in American youth. Future Plans: Our efforts on the NCS-R as an independent project have been significantly reduced over the past year, since the analyses of the most relevant topics to our research programs have been completed. However, we plan to continue to work with these data from this rich nationally representative sample to conduct comparative analyses of symptom patterns, correlates and consequences of disorders shown in our parallel adolescent sample.

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Rao, Aruna S; Scher, Ann I; Vieira, Rebeca V A et al. (2015) The Impact of Post-Traumatic Stress Disorder on the Burden of Migraine: Results From the National Comorbidity Survey-Replication. Headache 55:1323-41
Peterlin, B Lee; Rosso, Andrea L; Williams, Michelle A et al. (2013) Episodic migraine and obesity and the influence of age, race, and sex. Neurology 81:1314-21
Merikangas, Kathleen R (2013) Contributions of epidemiology to our understanding of migraine. Headache 53:230-46
Lamers, Femke; Burstein, Marcy; He, Jian-ping et al. (2012) Structure of major depressive disorder in adolescents and adults in the US general population. Br J Psychiatry 201:143-50
Merikangas, Kathleen R; McClair, Vetisha L (2012) Epidemiology of substance use disorders. Hum Genet 131:779-89
Fiedorowicz, Jess G; He, Jianping; Merikangas, Kathleen R (2011) The association between mood and anxiety disorders with vascular diseases and risk factors in a nationally representative sample. J Psychosom Res 70:145-54
Lateef, Tarannum; Swanson, Sonja; Cui, Lihong et al. (2011) Headaches and sleep problems among adults in the United States: findings from the National Comorbidity Survey-Replication study. Cephalalgia 31:648-53
Swendsen, Joel; Conway, Kevin P; Degenhardt, Louisa et al. (2010) Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the National Comorbidity Survey. Addiction 105:1117-28
Nierenberg, A A; Akiskal, H S; Angst, J et al. (2010) Bipolar disorder with frequent mood episodes in the national comorbidity survey replication (NCS-R). Mol Psychiatry 15:1075-87
Angst, Jules; Cui, Lihong; Swendsen, Joel et al. (2010) Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication. Am J Psychiatry 167:1194-201

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