We have developed pedigree-based rare variants analysis approach by treating each affected relatives as dependent pairs and the dependency will be accounted for using correlation matrix. This work led to two publications. We are now working on using a haplotype-based approach to identify causal variants for human diseases such as schizophrenia, bipolar and obsessive compulsive disorder. We have obtained the relevant data sets from dbGap which will allow us to compare the statistical properties (in an empirical sense) given by various types of analytical methods. In the future, we will also make contribution to a bipolar study in the Plain People in the Amish community, led by Dr. Francis McMahon (Chief, Human Genetics Branch, Intramural Research Program).
|Samuels, Jack; Shugart, Yin Yao; Wang, Ying et al. (2014) Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study. Am J Med Genet B Neuropsychiatr Genet 165B:326-36|
|Guo, Wei; Shugart, Yin Yao (2014) The power comparison of the haplotype-based collapsing tests and the variant-based collapsing tests for detecting rare variants in pedigrees. BMC Genomics 15:632|
|Yuan, Jianmin; Jin, Chunhui; Qin, Hai-De et al. (2013) Replication study confirms link between TSPAN18 mutation and schizophrenia in Han Chinese. PLoS One 8:e58785|
|Fan, Qin; He, Jun-Fang; Wang, Qi-Rui et al. (2013) Functional polymorphism in the 5'-UTR of CR2 is associated with susceptibility to nasopharyngeal carcinoma. Oncol Rep 30:11-6|
|Ruan, Hong-Lian; Qin, Hai-De; Shugart, Yin Yao et al. (2013) Developing genetic epidemiological models to predict risk for nasopharyngeal carcinoma in high-risk population of China. PLoS One 8:e56128|
|Chen, D T; Jiang, X; Akula, N et al. (2013) Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Mol Psychiatry 18:195-205|