Abstract

We have developed pedigree-based rare variants analysis approach by treating each affected relatives as dependent pairs and the dependency will be accounted for using correlation matrix. This work led to two publications. We are now working on using a haplotype-based approach to identify causal variants for human diseases such as schizophrenia, bipolar and obsessive compulsive disorder. We have obtained the relevant data sets from dbGap which will allow us to compare the statistical properties (in an empirical sense) given by various types of analytical methods. In the future, we will also make contribution to a bipolar study in the Plain People in the Amish community, led by Dr. Francis McMahon (Chief, Human Genetics Branch, Intramural Research Program).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAMH002930-03
Application #
8745754
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2013
Total Cost
$347,588
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Guo, W; Samuels, J F; Wang, Y et al. (2017) Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD. Eur Neuropsychopharmacol 27:657-666
Tao, Yu; Gao, Hui; Ackerman, Benjamin et al. (2016) Evidence for contribution of common genetic variants within chromosome 8p21.2-8p21.1 to restricted and repetitive behaviors in autism spectrum disorders. BMC Genomics 17:163
Qin, H; Samuels, J F; Wang, Y et al. (2016) Whole-genome association analysis of treatment response in obsessive-compulsive disorder. Mol Psychiatry 21:270-6
Qin, Hai-De; Liao, Xiao-Yu; Chen, Yuan-Bin et al. (2016) Genomic Characterization of Esophageal Squamous Cell Carcinoma Reveals Critical Genes Underlying Tumorigenesis and Poor Prognosis. Am J Hum Genet 98:709-27
Xu, Meng Yuan; Umbach, David M; Murphy, Eleanor et al. (2015) A Novel Mixture Model to Estimate the Time to Drug Effect Onset and Its Association with Covariates. Hum Hered 80:90-9
Wang, Yi; Li, Yi; Cao, Hongbao et al. (2015) Efficient test for nonlinear dependence of two continuous variables. BMC Bioinformatics 16:260
Wang, Jicai; Cao, Hongbao; Liao, Yanhui et al. (2015) Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings. Neuroimage Clin 8:95-103
Zhang, Fuquan; Xu, Yong; Cao, Hongbao et al. (2015) Mapsnp: an R package to plot a genomic map for single nucleotide polymorphisms. PLoS One 10:e0123609
Zhang, Fuquan; Xu, Yong; Shugart, Yin Yao et al. (2015) Converging evidence implicates the abnormal microRNA system in schizophrenia. Schizophr Bull 41:728-35
Wang, Zhiqiang; Yang, Bixiu; Liu, Yansong et al. (2015) Further evidence supporting the association of NKAPL with schizophrenia. Neurosci Lett 605:49-52

Showing the most recent 10 out of 31 publications