The Biophysics Core Facility service to the NIH scientific community consists of four main categories: direct research support, including instrument use, collaboration on research projects and scientific consultations; development and optimization of measurement methods, and user training. In the reporting period the total workload of the Biophysics Core Facility exceeded 2,300 user/hours. During this time, the Biophysics Core Facility users included principal investigators, staff scientists, postdocs and students from the following labs: NHLBI laboratories (by the PI last name): Alushin, Gregory; Burg, Maurice; Ferre-DAmare, Adrian; Geller, Herbert; Hammer, John; Hogg, Bobby; Korn, Edward; Larochelle, Andre; Lee, Jennifer; Levine, Rodney; Neuman, Keir; Remaley, Alan; Roll-Mecak, Antonina; Sellers, James; Taraska, Justin; Tjandra, Nico. Other NIH laboratories: Becerra, Patrica (NEI); Buchanan, Susan (NIDDK); Chiorini, Jay (NIDCR); Daly, Michael (USUHS); Gottesman, Susan (NCI-NHLBI); Grisshammer, Reinhard (NINDS); Kwong, Peter (NIAID); Neckers, Len (NCI); Roberts, David (NCI); Sartorelli, Vittorio (NIAMS); Tarasova, Nadya (NCI); Wickner, Sue (NCI); Wistow, Graeme (NEI); Youle, Richard (NINDS).

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
U.S. National Heart Lung and Blood Inst
Zip Code
Hayoz, Sebastien; Tiwari, Purushottam B; Piszczek, Grzegorz et al. (2017) Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance. PLoS One 12:e0185359
Liu, Xiong; Billington, Neil; Shu, Shi et al. (2017) Effect of ATP and regulatory light-chain phosphorylation on the polymerization of mammalian nonmuscle myosin II. Proc Natl Acad Sci U S A 114:E6516-E6525
O'Neil, Patrick K; Richardson, Lynn G L; Paila, Yamuna D et al. (2017) The POTRA domains of Toc75 exhibit chaperone-like function to facilitate import into chloroplasts. Proc Natl Acad Sci U S A 114:E4868-E4876
Jung, Goeh; Alexander, Christopher J; Wu, Xufeng S et al. (2016) V-1 regulates capping protein activity in vivo. Proc Natl Acad Sci U S A 113:E6610-E6619
Liu, W; Li, H; Hong, S-H et al. (2016) Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice. Oncogene :
Paez-Segala, Maria G; Sun, Mei G; Shtengel, Gleb et al. (2015) Fixation-resistant photoactivatable fluorescent proteins for CLEM. Nat Methods 12:215-8, 4 p following 218
Zhao, Huaying; Piszczek, Grzegorz; Schuck, Peter (2015) SEDPHAT--a platform for global ITC analysis and global multi-method analysis of molecular interactions. Methods 76:137-148
Zhao, Huaying; Ghirlando, Rodolfo; Alfonso, Carlos et al. (2015) A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLoS One 10:e0126420
Gruschus, James M; Jiang, Zhiping; Yap, Thai Leong et al. (2015) Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C. Biochem Biophys Res Commun 457:561-6
Yu, Xiaozhen; Strub, Marie-Paule; Barnard, Travis J et al. (2014) An engineered palette of metal ion quenchable fluorescent proteins. PLoS One 9:e95808

Showing the most recent 10 out of 36 publications