The Animal MRI Core has performed MRI studies on 13 projects from Oct. 1, 2012 to Sept 30, 2013. An additional two studies were manuscript preparation only. Currently active projects are listed below, alphabetically by Principal Investigator: 1. Arai, Andrew, NHLBI protocol H-0176. Rat Myocardial Fibrosis. High resolution MRI of rat heart in age-related fibrosis, acute MI, and chronic MI. Novel approach to imaging fresh gadolinium-exposed tissue immediately post-mortem with retention of gadolinium distribution in the tissue. Correlation of microimaging cellular level areas of fibrosis to microscopy and histopathology. Fellows Pascale Beliveau, Sophia Hammer-Hansen. 2. Boehm, Manfred, NHLBI Protocol H-0184.Imaging Mouse vascular grafts. Fellow Dan Yang. 3. Boehm, Manfred, NHLBI Protocol H-0038R2. Imaging teratoma anatomy, perfusion and vascular calcification (MRI and CT). Teratomas generated in mice using cells from normal volunteers, Jobs disease patients, and ACDC patients;fellow Cynthia St. Hilaire. 4. Darling, Thomas (USUHS, NCI) and Moss, Joel (NHLBI). NHLBI Protocol H-0128R2. Full body characterization of a tuberous sclerosis model in mice, with abnormalities of skin, bone, lymph nodes, muscles, kidneys and other organs;identifying frequency and type of abnormalities and effect of increasing age. Fellow Peter Klover (USUHS). 5. Moss, Joel, NHLBI protocol H-0172R2: Characterization of cardiac function in three models: double KO-ARH1KO&CD38KO;fellow Jiro Kato. 6. Moss, Joel, NHLBI protocol H-0193R2: Characterization of phenotype with whole body imaging of a Lymphangioleiomyomatosis (LAM) model. Fellow Jiro Kato. 7. Moss, Joel, NHLBI protocol H-0193R2: Characterization of ARH3 mice response to cardiac ischemia-reperfusion injury using cardiac MRI. Fellows Jiro Kato and Xiangning Bu. 8.Murphy, Philip, NIAID protocol LMI8E. Cardiac function in ApoE KO and DKO mice. Fellow Wuzhou Wan. 9.Remaley, Alan, NHLBI - Investigation of 19F imaging and spectroscopy for detection of a 19F substituted cholesteryl ester analogue, with input into further changes to the molecule for imaging and potentially tracking labeled cells. Collaborating scientists Alexander Bogdanov, CC, and Gary Griffiths, NHLBI. 10. Sack, Michael, NHLBI protocol H-0222R1. Anatomic and cardiac functional characterization of Parkin model mice with aortic banding surgery vs. WT and sham mice. Staff Scientist Kim Han, NHLBI. 11. Segars, James, NICHD protocol 12-060. Cardiac function and stress testing of floxed Brx knockout mice. 12. Springer, Danielle, NHLBI Phenotyping Core. Imaging areas of interest in aged mice and Cast-3 mice. 13. Wen, Han, NHLBI: Imaging ex vivo mouse kidney for comparison to a new X-ray imaging technique. Manuscript preparation for previously completed studies: 1. Bustin M., NCI. Subject: Characterization of cardiac function in HMGN KO and transgenic mouse lines. 2. Tabak L., NICHD. Subject: Galnt1 in heart development and function in mice.

Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$363,386
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Lipinski, Michael J; Albelda, M Teresa; Frias, Juan C et al. (2016) Multimodality imaging demonstrates trafficking of liposomes preferentially to ischemic myocardium. Cardiovasc Revasc Med 17:106-12
Beliveau, Pascale; Cheriet, Farida; Anderson, Stasia A et al. (2015) Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation. Comput Biol Med 65:103-13
Holmström, Kira M; Pan, Xin; Liu, Julia C et al. (2015) Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter. J Mol Cell Cardiol 85:178-82
Furusawa, Takashi; Rochman, Mark; Taher, Leila et al. (2015) Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun 6:6138
Tian, E; Stevens, Sharon R; Guan, Yu et al. (2015) Galnt1 is required for normal heart valve development and cardiac function. PLoS One 10:e0115861
Wan, Wuzhou; Liu, Qian; Lionakis, Michail S et al. (2015) Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice. Cardiovasc Res 106:478-87
Song, Minjung; San, Hong; Anderson, Stasia A et al. (2014) Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria. Stem Cell Res Ther 5:41
Wen, Han; Gomella, Andrew A; Patel, Ajay et al. (2013) Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings. Nat Commun 4:2659
Chen, Chia-Yen; Chi, Ya-Hui; Mutalif, Rafidah Abdul et al. (2012) Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell 149:565-77
Lau, Joe F; Anderson, Stasia A; Adler, Eric et al. (2010) Imaging approaches for the study of cell-based cardiac therapies. Nat Rev Cardiol 7:97-105

Showing the most recent 10 out of 17 publications