Abstract

The Animal MRI Core has performed MRI studies, data analysis, and/or manuscript preparation input on the following projects from Oct. 1, 2017 to Sept 30, 2018. Projects are listed alphabetically by Principal Investigator: 1. Elinoff, Jason (CC). Pulmonary hypertension models, including Rat hypoxia/normoxia and murine CAV-1 KO; function, RV wall, ventricular volumes, RA dimension and LV eccentricity index. Two abstracts presented at American Thoracic Society meeting, 2017. 2. Frank, Joseph (CC). Cardiac function in a rat model testing the effect of focused pulsed ultrasound on cardiac function. 3. Kozel, Beth: Fellow Levin, Cardiac function in mouse models of pulmonary hypertension and/or diastolic dysfunction. 4. Liu, Chengyu (NHLBI): Imaging therapeutic device placement and cardiac function in a mouse myocardial infarction model with cellular therapy. 5. Moss, Joel, NHLBI. Fellows Pacheco and Kato. Data assistance and new mouse imaging planning. 6. Ottinger, Elizabeth. Therapeutics for Rare and Neglected Diseases (TRND), NCATS. Protocols NCI 14-103 and NHLBI H-0219. Efficacy study for treatment of cardiac hypertrophy in LEOPARD syndrome model mice. Second round completed in 2018.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICHL005909-11
Application #
9788003
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Klover, Peter J; Thangapazham, Rajesh L; Kato, Jiro et al. (2017) Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3. Elife 6:
Han, Kim; Hassanzadeh, Shahin; Singh, Komudi et al. (2017) Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress. Sci Rep 7:2093
Lipinski, Michael J; Albelda, M Teresa; Frias, Juan C et al. (2016) Multimodality imaging demonstrates trafficking of liposomes preferentially to ischemic myocardium. Cardiovasc Revasc Med 17:106-12
van der Pals, Jesper; Hammer-Hansen, Sophia; Nielles-Vallespin, Sonia et al. (2015) Temporal and spatial characteristics of the area at risk investigated using computed tomography and T1-weighted magnetic resonance imaging. Eur Heart J Cardiovasc Imaging 16:1232-40
Beliveau, Pascale; Cheriet, Farida; Anderson, Stasia A et al. (2015) Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation. Comput Biol Med 65:103-13
Wan, Wuzhou; Liu, Qian; Lionakis, Michail S et al. (2015) Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice. Cardiovasc Res 106:478-87
Holmström, Kira M; Pan, Xin; Liu, Julia C et al. (2015) Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter. J Mol Cell Cardiol 85:178-82
Tian, E; Stevens, Sharon R; Guan, Yu et al. (2015) Galnt1 is required for normal heart valve development and cardiac function. PLoS One 10:e0115861
Furusawa, Takashi; Rochman, Mark; Taher, Leila et al. (2015) Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun 6:6138
Song, Minjung; San, Hong; Anderson, Stasia A et al. (2014) Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria. Stem Cell Res Ther 5:41

Showing the most recent 10 out of 21 publications