During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have nearly completed a human-grade MRI guidewire that provides both tip and shaft visibility and provides assurance of safety during operation. We have developed a rigorous Good Laboratory Practice animal testing program. We have prepared a regulatory submission to allow first-in-human testing in the upcoming year. We continue to work on radio frequency heating safety tests of interventional MRI devices. We currently work on to develop a new general protocols to test heating safety of active intravascular devices during real time MRI procedures We continue to develop novel prototypes of catheters and implants to treat valvular and congenital heart disease. We have invented several new devices, including for catheter-based tricuspid valve repair, caval-aortic access, and large sheath access.

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National Heart, Lung, and Blood Institute
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Barbash, I M; Cecchini, S; Faranesh, A Z et al. (2013) MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Gene Ther 20:274-82
Ratnayaka, Kanishka; Faranesh, Anthony Z; Hansen, Michael S et al. (2013) Real-time MRI-guided right heart catheterization in adults using passive catheters. Eur Heart J 34:380-9
Halabi, Majdi; Ratnayaka, Kanishka; Faranesh, Anthony Z et al. (2013) Transthoracic delivery of large devices into the left ventricle through the right ventricle and interventricular septum: preclinical feasibility. J Cardiovasc Magn Reson 15:10
Bell, Jamie A; Saikus, Christina E; Ratnayaka, Kanishka et al. (2012) A deflectable guiding catheter for real-time MRI-guided interventions. J Magn Reson Imaging 35:908-15
Bell, Jamie A; Saikus, Christina E; Ratnayaka, Kanishka et al. (2012) Active delivery cable tuned to device deployment state: enhanced visibility of nitinol occluders during preclinical interventional MRI. J Magn Reson Imaging 36:972-8
Sonmez, Merdim; Saikus, Christina E; Bell, Jamie A et al. (2012) MRI active guidewire with an embedded temperature probe and providing a distinct tip signal to enhance clinical safety. J Cardiovasc Magn Reson 14:38
Barbash, Israel M; Saikus, Christina E; Ratnayaka, Kanishka et al. (2011) Limitations of closing percutaneous transthoracic ventricular access ports using a commercial collagen vascular closure device. Catheter Cardiovasc Interv 77:1079-85
Barbash, Israel M; Schenke, William H; Halabi, Majdi et al. (2011) Experimental model of large pulmonary embolism employing controlled release of subacute caval thrombus in swine. J Vasc Interv Radiol 22:1471-7
Barbash, Israel M; Saikus, Christina E; Faranesh, Anthony Z et al. (2011) Direct percutaneous left ventricular access and port closure: pre-clinical feasibility. JACC Cardiovasc Interv 4:1318-25
Saikus, Christina E; Ratnayaka, Kanishka; Barbash, Israel M et al. (2011) MRI-guided vascular access with an active visualization needle. J Magn Reson Imaging 34:1159-66

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