Abstract

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have nearly completed a human-grade MRI guidewire that provides both tip and shaft visibility and provides assurance of safety during operation. We have developed a rigorous Good Laboratory Practice animal testing program. We are preparing a regulatory submission to allow first-in-human testing in the upcoming year. We continue to work on radio frequency heating safety tests of interventional MRI devices. We currently work on to develop a new general protocols to test heating safety of active intravascular devices during real time MRI procedures We continue to develop novel prototypes of catheters and implants to treat valvular and congenital heart disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICHL006041-03
Application #
8558140
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2012
Total Cost
$807,617
Indirect Cost

  Institution

Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Ratnayaka, Kanishka; Faranesh, Anthony Z; Hansen, Michael S et al. (2013) Real-time MRI-guided right heart catheterization in adults using passive catheters. Eur Heart J 34:380-9
Barbash, I M; Cecchini, S; Faranesh, A Z et al. (2013) MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Gene Ther 20:274-82
Halabi, Majdi; Ratnayaka, Kanishka; Faranesh, Anthony Z et al. (2013) Transthoracic delivery of large devices into the left ventricle through the right ventricle and interventricular septum: preclinical feasibility. J Cardiovasc Magn Reson 15:10
Bell, Jamie A; Saikus, Christina E; Ratnayaka, Kanishka et al. (2012) A deflectable guiding catheter for real-time MRI-guided interventions. J Magn Reson Imaging 35:908-15
Sonmez, Merdim; Saikus, Christina E; Bell, Jamie A et al. (2012) MRI active guidewire with an embedded temperature probe and providing a distinct tip signal to enhance clinical safety. J Cardiovasc Magn Reson 14:38
Bell, Jamie A; Saikus, Christina E; Ratnayaka, Kanishka et al. (2012) Active delivery cable tuned to device deployment state: enhanced visibility of nitinol occluders during preclinical interventional MRI. J Magn Reson Imaging 36:972-8
Barbash, Israel M; Schenke, William H; Halabi, Majdi et al. (2011) Experimental model of large pulmonary embolism employing controlled release of subacute caval thrombus in swine. J Vasc Interv Radiol 22:1471-7
Barbash, Israel M; Saikus, Christina E; Faranesh, Anthony Z et al. (2011) Direct percutaneous left ventricular access and port closure: pre-clinical feasibility. JACC Cardiovasc Interv 4:1318-25
Saikus, Christina E; Ratnayaka, Kanishka; Barbash, Israel M et al. (2011) MRI-guided vascular access with an active visualization needle. J Magn Reson Imaging 34:1159-66
Ratnayaka, Kanishka; Saikus, Christina E; Faranesh, Anthony Z et al. (2011) Closed-chest transthoracic magnetic resonance imaging-guided ventricular septal defect closure in swine. JACC Cardiovasc Interv 4:1326-34

Showing the most recent 10 out of 17 publications