The transgenic model being generated is a strain of transgenic (TG) mice designed to express the mouse AF2ER mutant protein in a global or tissue specific manner by crossing with Cre expressing mice. Once the TG is incorporated this TG mouse will express beta galactosidase (LacZ) in the TG before crossing with Cre mice, after which the TG construct is activated to express the mutated ERa (AF2ER) protein. We will characterize the functionality of the AF2ER mutant receptor protein in specific tissues by the crossing with tissue specific Cre expressing mice or by way of a cross with a global expressing mouse line such as Sox2-Cre.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Resource and Support Contracts (N02)
Project #
273200700001I-0-27300002-1
Application #
8147321
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
2010
Total Cost
$44,716
Indirect Cost
Name
Xenogen Biosciences
Department
Type
DUNS #
City
Cranbury
State
NJ
Country
United States
Zip Code
08512