Abstract

32 chemicals (18 developmental toxicants, 7 neurotoxicants, 5 unknowns, and 3 negative controls) will be evaluated with a battery of assays in zebrafish embryos. The maximum tolerated concentration will be determined with 5 concentrations/compound (0.1-1000 ?M). Cardiotoxicity, behavioral alteration (i.e., neurotoxicity), and hepatotoxicity (n=10-20) following compound exposure will be evaluated conducted in zebrafish embryos.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Resource and Support Contracts (N02)
Project #
273201600004P-0-0-1
Application #
9367503
Study Section
Project Start
2015-10-16
Project End
2016-10-15
Budget Start
Budget End
Support Year
Fiscal Year
2016
Total Cost
Indirect Cost