Abstract

The specific aims of this project are to provide facilities that will expand ACHRI's' capacity by: 1) building 6 new laboratories to accommodate the growth of ongoing programs in neonatal pain, osteogenesis, and birth defects research; and 2) building 2 new laboratories that will facilitate recruitment of established, productive pediatric scientists in the area of developmental research. ACHRI will use this award to perform extensive interior renovation of 11,160 feet of existing, empty space to house 8 wet laboratories, 13 offices, a conference room, 2 tissue culture laboratories, a darkroom, a glassware room, chemical storage and an equipment room. The funds requested would provide critically needed laboratory and office space that are not currently available to pediatric researchers and which are vital to ongoing PHS-funded research. The planned facility expansion does not replace existing ACHRI facilities and will correct deficiencies and limitations in the present facilities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Facilities Construction Grant (C06)
Project #
3C06RR016517-01S1
Application #
6794519
Study Section
Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities (STRB)
Project Start
2001-09-30
Project End
2002-09-29
Budget Start
2001-09-30
Budget End
2002-09-29
Support Year
1
Fiscal Year
2002
Total Cost
$131,745
Indirect Cost

  Institution

Name
Arkansas Children's Hospital Research Institute
Department
Type
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72202

  Publications

Thrailkill, Kathryn M; Nyman, Jeffry S; Bunn, R Clay et al. (2017) The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes. Bone 94:141-151
Thrailkill, Kathryn M; Clay Bunn, R; Nyman, Jeffry S et al. (2016) SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice. Bone 82:101-7
Fowlkes, John L; Nyman, Jeffry S; Bunn, R Clay et al. (2015) Effects of long-term doxycycline on bone quality and strength in diabetic male DBA/2J mice. Bone Rep 1:16-19
Fowlkes, John L; Nyman, Jeffry S; Bunn, R Clay et al. (2013) Osteo-promoting effects of insulin-like growth factor I (IGF-I) in a mouse model of type 1 diabetes. Bone 57:36-40
Thrailkill, K M; Jo, C-H; Cockrell, G E et al. (2012) Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes. Osteoporos Int 23:1799-806
Fowlkes, John L; Bunn, R Clay; Cockrell, Gael E et al. (2011) Dysregulation of the intrarenal vitamin D endocytic pathway in a nephropathy-prone mouse model of type 1 diabetes. Exp Diabetes Res 2011:269378
Thrailkill, Kathryn M; Jo, Chan-Hee; Cockrell, Gael E et al. (2011) Enhanced excretion of vitamin D binding protein in type 1 diabetes: a role in vitamin D deficiency? J Clin Endocrinol Metab 96:142-9
Nyman, Jeffry S; Even, Jesse L; Jo, Chan-Hee et al. (2011) Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone. Bone 48:733-40
Bunn, Robert C; Cockrell, Gael E; Ou, Yang et al. (2010) Palmitate and insulin synergistically induce IL-6 expression in human monocytes. Cardiovasc Diabetol 9:73
Thrailkill, Kathryn M; Moreau, Cynthia S; Cockrell, Gael E et al. (2010) Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus. Endocrine 37:336-43

Showing the most recent 10 out of 25 publications