? ? Our Fogarty training program in India has focused on the development of skills and capacity building for research and interventions concerning the environmental health consequences resulting from widespread arsenic contamination of drinking water, especially in West Bengal, and the serious effects of indoor air pollution from use of traditional fuels in rural households throughout the country. ? ? The arsenic in water problem is even more widespread than it seemed five years ago and the health risks more devastating. As well as West Bengal, where there are more than six million people drinking arsenic contaminated water, the problem is now known to extend into the neighboring states of Bihar, Uttar Pradesh, and Assam, and into the lowlands of Nepal. The health risks were already known to be very high, and our work with trainees in India has identified additional effects including high rates of stillbirth, and marked increases in chronic respiratory disease including bronchiectasis. We plan to continue training in arsenic research with traditional and molecular epidemiology research studies, including investigations to assess the health impact of early life exposure to arsenic. Reduction of population exposure has been extremely slow, in part because arsenic in water is invisible, tasteless and odorless. We will continue to work with trainees to improve the design of shallow dugwells as a rapid mitigation method to reduce exposure while government sponsored long term solutions are gradually implemented. ? ? The large population exposed to indoor air pollution in India has been clear for some years, but understanding of health effects has been rapidly evolving. Recent findings include adverse birth outcomes cataracts, lung cancer, and tuberculosis, and possible effects on blood pressure and cardiovascular disease, in addition to the already known effects of chronic obstructive pulmonary disease in women and acute lower respiratory infections in children. Like arsenic in water, however, viable and cost-effective interventions are still elusive, largely due to social, economic, and perceptual constraints. Clean fuels are too expensive and simple chimney stoves turn out not to lower exposures to levels thought to be sufficiently protective for large-scale application. As with arsenic, it is our intention to conduct training in both traditional and modern methods of exposure and outcome assessment as well as to further explore the efficacy of such interventions as stoves with highly improved combustion of biomass so that less pollution is actually generated. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
3D43TW000815-12S1
Application #
7672864
Study Section
Special Emphasis Panel (ZES1-SET-E (D4))
Program Officer
Rosenthal, Joshua
Project Start
1996-09-30
Project End
2012-02-29
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
12
Fiscal Year
2008
Total Cost
$39,000
Indirect Cost
Name
University of California Berkeley
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Paul, Somnath; Das, Nandana; Bhattacharjee, Pritha et al. (2013) Arsenic-induced toxicity and carcinogenicity: a two-wave cross-sectional study in arsenicosis individuals in West Bengal, India. J Expo Sci Environ Epidemiol 23:156-62
Pokhrel, Amod K; Bates, Michael N; Shrestha, Sachet P et al. (2013) Biomass stoves and lens opacity and cataract in Nepalese women. Optom Vis Sci 90:257-68
Lakshmi, P V M; Virdi, Navkiran Kaur; Thakur, J S et al. (2012) Biomass fuel and risk of tuberculosis: a case-control study from Northern India. J Epidemiol Community Health 66:457-61
Das, Nandana; Paul, Somnath; Chatterjee, Debmita et al. (2012) Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India. BMC Public Health 12:639
Banerjee, Nilanjana; Nandy, Sujay; Kearns, James K et al. (2011) Polymorphisms in the TNF-? and IL10 gene promoters and risk of arsenic-induced skin lesions and other nondermatological health effects. Toxicol Sci 121:132-9
Basu, Arin; Mitra, Soma; Chung, Joyce et al. (2011) Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India. Environ Health Perspect 119:1308-13
Johnson, Priscilla; Balakrishnan, Kalpana; Ramaswamy, Padmavathi et al. (2011) Prevalence of chronic obstructive pulmonary disease in rural women of Tamilnadu: implications for refining disease burden assessments attributable to household biomass combustion. Glob Health Action 4:7226
Pokhrel, Amod K; Bates, Michael N; Verma, Sharat C et al. (2010) Tuberculosis and indoor biomass and kerosene use in Nepal: a case-control study. Environ Health Perspect 118:558-64
Hira-Smith, Meera M; Yuan, Yan; Savarimuthu, Xavier et al. (2007) Arsenic concentrations and bacterial contamination in a pilot shallow dugwell program in West Bengal, India. J Environ Sci Health A Tox Hazard Subst Environ Eng 42:89-95
von Ehrenstein, Ondine S; Poddar, Shalini; Yuan, Yan et al. (2007) Children's intellectual function in relation to arsenic exposure. Epidemiology 18:44-51

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