Abstract

This application for a Global Infectious Disease Research Training Program is for continuing support of an international joint training program in Infectious Disease research operated in partnership between Case Western Reserve University, the Division of Vector Borne Diseases of the Ministry of Health (Kenya) and the Kenya Medical Research Institute. The overall goal of this training project is to further expand the research and management skills of the Division of Vector Borne Diseases (DVBD) and to enhance DVBD's capacity for basic research.
The specific aims of the proposed CWRU-DVBD-KEMRI Global Infectious Disease Research Training Program are: 1. To provide intensive training in the research methodology of emerging infectious diseases to investigators, research staff, and other relevant individuals from Kenya; 2. To strengthen the scientific and administrative ties with researchers in Kenya; 3. To advance knowledge in the epidemiology, molecular pathogenesis, and genetic epidemiology of malaria, schistosomiasis, filariasis and arboviruses; 4. To train US counterparts to foreign scientists in the research methods relevant to the epidemiology and control of Infectious Diseases in developing countries; and, 5. To assist in the infrastructure development of collaborating research centers in Kenya. In order to achieve these goals, the program will provide a continuing program of education and collaborative research projects between CWRU and the Kenya Ministry of Health. Training options will include graduate degree training at the Masters and PhD level, post-doctoral training, focused short-term training for established investigators, and short-course seminars in Kenya for transfer of specific research skills. Depending on the needs of participating trainees, training may occur either at U.S. or Kenyan institutions. Selection of trainees and program oversight will be provided by a Training Advisory Group comprised of the program directors, program alumni, and local Kenyan and international research scientists.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW006576-02
Application #
6800024
Study Section
Special Emphasis Panel (ZRG1-ICP-2 (90))
Program Officer
Sina, Barbara J
Project Start
2003-09-05
Project End
2008-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
2
Fiscal Year
2004
Total Cost
$150,000
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Pinkevych, Mykola; Chelimo, Kiprotich; Vulule, John et al. (2015) Time-to-infection by Plasmodium falciparum is largely determined by random factors. BMC Med 13:19
Pinkevych, Mykola; Petravic, Janka; Chelimo, Kiprotich et al. (2014) Decreased growth rate of P. falciparum blood stage parasitemia with age in a holoendemic population. J Infect Dis 209:1136-43
Pinkevych, Mykola; Petravic, Janka; Chelimo, Kiprotich et al. (2013) Density-dependent blood stage Plasmodium falciparum suppresses malaria super-infection in a malaria holoendemic population. Am J Trop Med Hyg 89:850-6
Chattopadhyay, Pratip K; Chelimo, Kiprotich; Embury, Paula B et al. (2013) Holoendemic malaria exposure is associated with altered Epstein-Barr virus-specific CD8(+) T-cell differentiation. J Virol 87:1779-88
Dent, Arlene E; Moormann, Ann M; Yohn, Christopher T et al. (2012) Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection. Malar J 11:287
Pinkevych, Mykola; Petravic, Janka; Chelimo, Kiprotich et al. (2012) The dynamics of naturally acquired immunity to Plasmodium falciparum infection. PLoS Comput Biol 8:e1002729
Chelimo, Kiprotich; Embury, Paula B; Sumba, Peter Odada et al. (2011) Age-related differences in naturally acquired T cell memory to Plasmodium falciparum merozoite surface protein 1. PLoS One 6:e24852
LaBeaud, A Desiree; Sutherland, Laura J; Muiruri, Samuel et al. (2011) Arbovirus prevalence in mosquitoes, Kenya. Emerg Infect Dis 17:233-41
Spring, Michele D; Chelimo, Kiprotich; Tisch, Daniel J et al. (2010) Allele specificity of gamma interferon responses to the carboxyl-terminal region of Plasmodium falciparum merozoite surface protein 1 by Kenyan adults with naturally acquired immunity to malaria. Infect Immun 78:4431-41
Sumba, P O; Kabiru, E W; Namuyenga, E et al. (2010) Microgeographic variations in Burkitt's lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr virus. Br J Cancer 103:1736-41

Showing the most recent 10 out of 12 publications