This is a competitive renewal application to support continuation of a training program in malaria research begun in Uganda in 2000.
Aims of our program will be: 1) to increase the expertise of our trainees in relevant clinical, epidemiological, and molecular research on malaria, 2) to strengthen the sustainability of malaria research in Uganda, 3) to expand research interactions between Ugandan and American scientists, 4) to strengthen trainee contributions to evidence-based decision-making, 5) to optimize training through utilization of additional available resources in Uganda, and 6) to strengthen research capacity in Uganda by helping trainees to integrate into Ugandan institutions and pursue independently-supported scientific careers.Trainees will be chosen among Ugandan junior scientists with interests in malaria research, and will enter either clinical, epidemiology, or molecular research tracks. When possible, training will be linked to ongoing research projects in Uganda. Formal training will be principally at the Masters level, although some more advanced training at the PhD or postdoctoral level will also be available. Training will be available at Makerere University in Kampala, Uganda, at the University of California, San Francisco and Berkeley, and in sandwich programs involving multiple institutions.

Public Health Relevance

This program will train Ugandan junior investigators in clinical malaria research. The program will be highly relevant, as an improved infrastructure for research on malaria is needed in countries endemic for this disease. A key part of this improved infrastructure is a growing base of research experts, as will be facilitated for Uganda by this award.

National Institute of Health (NIH)
Fogarty International Center (FIC)
International Research Training Grants (D43)
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Special Emphasis Panel (ZRG1-ICP2-B (50))
Program Officer
Sina, Barbara J
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Mpimbaza, Arthur; Walakira, Andrew; Ndeezi, Grace et al. (2018) Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. PLoS One 13:e0203229
Mpimbaza, Arthur; Ndeezi, Grace; Katahoire, Anne et al. (2017) Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study. Am J Trop Med Hyg 97:1513-1523
Walakira, Andrew; Tukwasibwe, Stephen; Kiggundu, Moses et al. (2017) Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol 55:281-287
Tukwasibwe, Stephen; Tumwebaze, Patrick; Conrad, Melissa et al. (2017) Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. Malar J 16:125
Rosenthal, Philip J; Bausch, Daniel G; Higgs, Stephen et al. (2017) Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States. Am J Trop Med Hyg 96:5-6
Tumwebaze, Patrick; Tukwasibwe, Stephen; Taylor, Aimee et al. (2017) Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda. J Infect Dis 215:631-635
Asua, Victor; Tukwasibwe, Stephen; Conrad, Melissa et al. (2017) Plasmodium Species Infecting Children Presenting with Malaria in Uganda. Am J Trop Med Hyg 97:753-757
Ssewanyana, Isaac; Arinaitwe, Emmanuel; Nankabirwa, Joaniter I et al. (2017) Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Malar J 16:67
Nankabirwa, Joaniter I; Conrad, Melissa D; Legac, Jennifer et al. (2016) Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity. Antimicrob Agents Chemother 60:5649-54
Cooper, Roland A; Conrad, Melissa D; Watson, Quentin D et al. (2015) Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. Antimicrob Agents Chemother 59:5061-4

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