China has one of the world's fastest-growing economies and scientific enterprises, and there are strong economic, scientific and cultural ties between Northern California and China. The DC Davis-China Infectious Diseases Research Training Program will address mutual interests and gaps in our understanding of the transmission, pathogenesis, and public health impact of infectious diseases of global importance, specifically tuberculosis. The major goals of the five-year training program are 1) to build sustainable research capacity at Fudan University and Shanghai Municipal Center for Disease Control and Prevention (Shanghai CDC) and 2) to increase the capacity of our respective biomedical and public health communities to rapidly collect, manage, exchange and interpret information that spans diverse scientific fields for the prevention and control infectious diseases, particularly tuberculosis. The proposed research training initiative will build on an established collaboration and will provide support to help develop a critical mass of research scientists and public health practitioners at two institutions in China. Training will take place in both the United States and China, using training faculty and facilities at UC Davis, Fudan University and Shanghai CDC, and collaborating laboratories and institutions. Research training will be provided to 1) researchers who are completing the master's or doctoral degree programs at Fudan University, and 2) laboratory scientists, technicians, or public health professionals. Trainees will complete short-term training in California for 6-12 month periods, followed by research in degree programs in China and in-country short, intensive courses and workshops to share and disseminate new knowledge and skills in China. We will use a combination of strategies to facilitate successful re-integration and the development of academic and professional careers in China. The program will develop three training tracks: 1) state-of-the-art microbiology for research and public health practice;2) field and molecular epidemiology;and 3) biostatistics and bioinformatics. Trainees will participate in short courses of the UC Davis Lab Management Institute, UC Davis Biotechnology Program, UC Davis Responsible Conduct of Research, and the Francis J. Curry National Tuberculosis Center. A Training Advisory Group will provide oversight and assess the program's progress, and we include an annual training evaluation plan.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW007887-05
Application #
8251001
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Sina, Barbara J
Project Start
2008-08-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2012
Total Cost
$140,098
Indirect Cost
$10,378
Name
University of California Davis
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Yang, Chongguang; Luo, Tao; Shen, Xin et al. (2017) Transmission of multidrug-resistant Mycobacterium tuberculosis in Shanghai, China: a retrospective observational study using whole-genome sequencing and epidemiological investigation. Lancet Infect Dis 17:275-284
Shen, Xin; Yang, Chongguang; Wu, Jie et al. (2017) Recurrent tuberculosis in an urban area in China: Relapse or exogenous reinfection? Tuberculosis (Edinb) 103:97-104
Dong, Xinran; Wang, Xiao; Zhang, Feng et al. (2016) Genome-Wide Identification of Regulatory Sequences Undergoing Accelerated Evolution in the Human Genome. Mol Biol Evol 33:2565-75
Dong, Xinran; Hao, Yun; Wang, Xiao et al. (2016) LEGO: a novel method for gene set over-representation analysis by incorporating network-based gene weights. Sci Rep 6:18871
Liu, Qingyun; Luo, Tao; Dong, Xinran et al. (2016) Genetic features of Mycobacterium tuberculosis modern Beijing sublineage. Emerg Microbes Infect 5:e14
Yang, Chongguang; Shen, Xin; Peng, Ying et al. (2015) Transmission of Mycobacterium tuberculosis in China: a population-based molecular epidemiologic study. Clin Infect Dis 61:219-27
Luo, Tao; Yang, Chongguang; Peng, Ying et al. (2014) Whole-genome sequencing to detect recent transmission of Mycobacterium tuberculosis in settings with a high burden of tuberculosis. Tuberculosis (Edinb) 94:434-40
Bastos, Mayara L; Hussain, Hamidah; Weyer, Karin et al. (2014) Treatment outcomes of patients with multidrug-resistant and extensively drug-resistant tuberculosis according to drug susceptibility testing to first- and second-line drugs: an individual patient data meta-analysis. Clin Infect Dis 59:1364-74
Chen, Jing; Qi, Lihong; Xia, Zhen et al. (2013) Which urban migrants default from tuberculosis treatment in Shanghai, China? PLoS One 8:e81351
Liu, Qingyun; Luo, Tao; Li, Jing et al. (2013) Triplex real-time PCR melting curve analysis for detecting Mycobacterium tuberculosis mutations associated with resistance to second-line drugs in a single reaction. J Antimicrob Chemother 68:1097-103

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