Abstract

WeproposetostrengthenandsustainourinternationalResearchTrainingProgramshared betweenTheOhioStateUniversityandInstitutesofHigherLearningineastAfrica.Expanding thesuccessesinthefirstcycle,thelong-termgoalofthisprogramistoestablishsustainable researchandtrainingcapacityforzonoticinfectiousdiseasesresearchineasternAfrica.The specificmissionoftheproposedprogramistotrainthefutureresearchersandtrainersusingan integratedmulti-disciplinaryOneHealthapproach.Theultimategoalistoestablishsustainable crticialmassofcapablescientiststhatcaneffectivelyconductresearchonzoonoticdiseases andimplementpreventionandcontrolsystems.Themaintargetsoftheproposedprogramare foureasternAfricanacademicinstitutes(UniversityofGondarandAddisAbabaUniversity, Ethiopia;?UniversityofNairobi,KenyaandSokoineUniversity,Tanzania).Food-water-and vector-borneinfectiousdiseasessuchasinvasivesalmonellosis,animal-bornetuberculosis, viralfood/waterbornepathogenandvector-bornediseasesaremajorglobalpublichealth concernswithahighmorbidityandmortalityinsub-SaharanAfrica.However,theresearch trainingcapacitiesintheregionremainextremelyweak.Inthecurrentcycle,wemadekey transformationstoincreasethesuccessofourprogramincluding:1)revampedpriorities includingwater-borneandvector-bornediseasessuch;?2)refineddisciplineareasarenowmore targetedandmeasureablesuchasrapiddiagnosticdevelopment,antimicrobialresistanceand genomics;?3)intergatedelectronicanddigitalapproachesforresearchandtrainingtomaximize theimpactofourprogramand4)emphasizedscientificleadershipandimplementationscience, tomaximizeimpactandsustainresults.Thisresearchtrainingprogramwillbeconductedusing twoTracks:Track1isasandwichformatpre-doctoraltrainingforPhDandMSc.Traineeswill haveampleopportunitiesatOSUleveragedwithresearchareasincludingrotavirus, salmonellosis,tuberculosisandLeishmaniasis.Track2willinvolveashort-termtrainingthatwill targetlaboratorytechnologists.Thisresearchtrainingprogramalsowillstrengthenintra-regional collaborationamongscientistsincludingveterinarians,physiciansandenvironmentalhealth scientiststoeffectivelyaddresszoonoticdiseases.

Public Health Relevance

PROJECTSUMMARY WeproposetostrengthenandsustainourinternationalResearchTrainingProgramshared betweenTheOhioStateUniversityandInstitutesofHigherLearningineastAfrica.Expanding thesuccessesinthefirstcycle,thelong-termgoalofthisprogramistoestablishsustainable researchandtrainingcapacityforzonoticinfectiousdiseasesresearchineasternAfrica.The specificmissionoftheproposedprogramistotrainthefutureresearchersandtrainersusingan integratedmulti-disciplinary'OneHealth'approach.Theultimategoalistoestablishsustainable crticialmassofcapablescientiststhatcaneffectivelyconductresearchonzoonoticdiseases andimplementpreventionandcontrolsystems.Themaintargetsoftheproposedprogramare foureasternAfricanacademicinstitutes(UniversityofGondarandAddisAbabaUniversity, Ethiopia;?UniversityofNairobi,KenyaandSokoineUniversity,Tanzania).Food-water-and vector-borneinfectiousdiseasessuchasinvasivesalmonellosis,animal-bornetuberculosis, viralfood/waterbornepathogenandvector-bornediseasesaremajorglobalpublichealth concernswithahighmorbidityandmortalityinsub-SaharanAfrica.However,theresearch trainingcapacitiesintheregionremainextremelyweak.Inthecurrentcycle,wemadekey transformationstoincreasethesuccessofourprogramincluding:1)revampedpriorities includingwater-borneandvector-bornediseasessuch;?2)refineddisciplineareasarenowmore targetedandmeasureablesuchasrapiddiagnosticdevelopment,antimicrobialresistanceand genomics;?3)intergatedelectronicanddigitalapproachesforresearchandtrainingtomaximize theimpactofourprogramand4)emphasizedscientificleadershipandimplementationscience, tomaximizeimpactandsustainresults.Thisresearchtrainingprogramwillbeconductedusing twoTracks:Track1isasandwichformatpre-doctoraltrainingforPhDandMSc.Traineeswill haveampleopportunitiesatOSUleveragedwithresearchareasincludingrotavirus, salmonellosis,tuberculosisandLeishmaniasis.Track2willinvolveashort-termtrainingthatwill targetlaboratorytechnologists.Thisresearchtrainingprogramalsowillstrengthenintra-regional collaborationamongscientistsincludingveterinarians,physiciansandenvironmentalhealth scientiststoeffectivelyaddresszoonoticdiseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
3D43TW008650-08S1
Application #
10131527
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Sina, Barbara J
Project Start
2010-06-01
Project End
2023-02-28
Budget Start
2020-03-01
Budget End
2021-02-28
Support Year
8
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Ohio State University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210

  Publications

Eguale, Tadesse; Birungi, Josephine; Asrat, Daniel et al. (2017) Genetic markers associated with resistance to beta-lactam and quinolone antimicrobials in non-typhoidal Salmonella isolates from humans and animals in central Ethiopia. Antimicrob Resist Infect Control 6:13
Eguale, Tadesse; Engidawork, Ephrem; Gebreyes, Wondwossen A et al. (2016) Fecal prevalence, serotype distribution and antimicrobial resistance of Salmonellae in dairy cattle in central Ethiopia. BMC Microbiol 16:20
Eguale, Tadesse; Gebreyes, Wondwossen A; Asrat, Daniel et al. (2015) Non-typhoidal Salmonella serotypes, antimicrobial resistance and co-infection with parasites among patients with diarrhea and other gastrointestinal complaints in Addis Ababa, Ethiopia. BMC Infect Dis 15:497
Kashoma, Isaac P; Kumar, Anand; Sanad, Yasser M et al. (2014) Phenotypic and genotypic diversity of thermophilic Campylobacter spp. in commercial turkey flocks: a longitudinal study. Foodborne Pathog Dis 11:850-60
Eguale, Tadesse; Marshall, Joanna; Molla, Bayleyegn et al. (2014) Association of multicellular behaviour and drug resistance in Salmonella enterica serovars isolated from animals and humans in Ethiopia. J Appl Microbiol 117:961-971
Medardus, Julius J; Molla, Bayleyegn Z; Nicol, Matthew et al. (2014) In-feed use of heavy metal micronutrients in U.S. swine production systems and its role in persistence of multidrug-resistant salmonellae. Appl Environ Microbiol 80:2317-25
Amimo, Joshua O; Okoth, Edward; Junga, Joseph O et al. (2014) Molecular detection and genetic characterization of kobuviruses and astroviruses in asymptomatic local pigs in East Africa. Arch Virol 159:1313-9
Sisay, Zufan; Wang, Qiuhong; Oka, Tomoichiro et al. (2013) Prevalence and molecular characterization of porcine enteric caliciviruses and first detection of porcine kobuviruses in US swine. Arch Virol 158:1583-8
Amimo, J O; Vlasova, A N; Saif, L J (2013) Prevalence and genetic heterogeneity of porcine group C rotaviruses in nursing and weaned piglets in Ohio, USA and identification of a potential new VP4 genotype. Vet Microbiol 164:27-38
Amimo, J O; Vlasova, A N; Saif, L J (2013) Detection and genetic diversity of porcine group A rotaviruses in historic (2004) and recent (2011 and 2012) swine fecal samples in Ohio: predominance of the G9P[13] genotype in nursing piglets. J Clin Microbiol 51:1142-51

Showing the most recent 10 out of 11 publications