The WHO estimates that NCDs are the 2nd leading cause of death in sub-Saharan Africa (SSA), accounting for 30% of the 9.5 million deaths in Africa. The number of people with hypertension in SSA will increase by 68% from 75 million in 2008 to 126 million in 2025. In Ghana and Nigeria, the burden of stroke and CVD has grown in the past decade; and it is estimated that the scant resources in SSA countries would be depleted by the disability from CVD if this epidemic go unabated. Thus, strengthening research capacity in prevention of stroke and CVD is an urgent priority. However, research productivity and collaboration among African scientists is abysmally low. In order to address this problem, we developed a Cardiovascular Research Training (CaRT) program (D43TW009140; MPI: Ogedegbe, Adanu & Tayo) that trained 64 investigators between 2012-2017 in Ghana and Nigeria. Led by 4 accomplished African scholars (Ogedegbe, Adanu, Ovbiagele & Tayo), this renewal application, will broaden the scope of CaRT to include stroke prevention. The proposed program, known as Stroke-CaRT, is a consortium of NYU, UCSF, Loyola University and two African countries (Ghana and Nigeria). We will enroll 100 trainees in 4 cohorts of 25 trainees (12-13 from each country) in either a Health Services Research (HSR) track or a Patient-Oriented Research (POR) track. Trainees in the HSR track will be chosen from candidates with a background in public health (nurses, pharmacists, etc.), while those in the POR track will be chosen from a pool of physicians enrolled in postgraduate residency programs. The unifying theme of both tracks is trainees? common interest in stroke and CVD. The 2-year program comprises: (a) three 2-week Intensive Research Courses in Year 1; and (b) a Mentored Research Experience in Year 2, during which trainees will conduct Mentored Research Projects and attend monthly Advance Seminars via WebEx to discuss their progress. We will utilize a multidisciplinary ?twinning? strategy whereby trainees with similar expertise will be paired to work in teams of 4 [two from each country] in order to foster between-country collaborations. The program is built on an infrastructure of NIH grants between the PIs and their colleagues in Ghana and Nigeria: Bioethics training grant (R25TW010886; Art & Ogedegbe); implementation research in HTN (U01HL138638; Ogedegbe) and stroke (R21 NS103752; Ovbiagele), stroke epidemiology (R01NS107900; R21TW010479 & U54HG007479; Ovbiagele); stroke genomics (R01NS107900; Ovbiagele) and primary stroke prevention in sickle cell disease (R01NS094041; Debaun M). The training will occur yearly in Ghana and Nigeria, rather than the United States, in order to mitigate the risk of ?brain drain? that is often inherent in sending African scholars abroad for training. Upon completion, trainees will acquire skills needed to conduct scientifically rigorous research in stroke prevention and CVD risk reduction in Africa. Our long-term goal is to develop a sustainable network of trainees with expertise in HSR and POR, who are poised to assume leadership roles in academia in SSA.

Public Health Relevance

S-CART will address a critical deficiency of African scientists committed to a career in stroke prevention and cardiovascular research. Successful completion of S-CART will lead to the establishment of a sustainable CVD research capacity and innovative and contextualized research projects targeted at stroke and CVD prevention.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW009140-07
Application #
10018676
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Michels, Kathleen M
Project Start
2011-09-05
Project End
2024-05-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Adeoye, Abiodun M; Tayo, Bamidele O; Owolabi, Mayowa O et al. (2018) Ambulatory blood pressure threshold for black Africans: more questions than answers. J Clin Hypertens (Greenwich) 20:847-849
Sarfo, Fred S; Owusu, Dorcas; Adamu, Sheila et al. (2018) Plasma Glial Fibrillary Acidic Protein, Copeptin, and Matrix Metalloproteinase-9 Concentrations among West African Stroke Subjects Compared with Stroke-Free Controls. J Stroke Cerebrovasc Dis 27:633-644
Sarfo-Kantanka, Osei; Sarfo, Fred Stephen; Ansah, Eunice Oparebea et al. (2017) Frequency and determinants of thyroid autoimmunity in Ghanaian type 2 diabetes patients: a case-control study. BMC Endocr Disord 17:2
Obed, Samuel Amenyi; Asah-Opoku, Kwaku; Aboagye, Serwah et al. (2017) Awareness of Sickle Cell Trait Status: A Cross-Sectional Survey of Antenatal Women in Ghana. Am J Trop Med Hyg 96:735-740
Bress, Adam P; Colantonio, Lisandro D; Booth 3rd, John N et al. (2017) Modifiable Risk Factors Versus Age on Developing High Predicted Cardiovascular Disease Risk in Blacks. J Am Heart Assoc 6:
Yorke, Ernest; Atiase, Yacoba; Akpalu, Josephine et al. (2017) Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know. Int J Endocrinol 2017:1547358
Iwelunmor, Juliet; Gyamfi, Joyce; Plange-Rhule, Jacob et al. (2017) Exploring stakeholders' perceptions of a task-shifting strategy for hypertension control in Ghana: a qualitative study. BMC Public Health 17:216
Adeoye, Abiodun M; Ogah, Okechukwu S; Ovbiagele, Bruce et al. (2017) Prevalence and Prognostic Features of ECG Abnormalities in Acute Stroke: Findings From the SIREN Study Among Africans. Glob Heart 12:99-105
Kayode, Gbenga Ayodele; Grobbee, Diederick E; Amoakoh-Coleman, Mary et al. (2017) Variation in neonatal mortality and its relation to country characteristics in sub-Saharan Africa: an ecological study. BMJ Glob Health 2:e000209
Saraf, Santosh L; Akingbola, Titilola S; Shah, Binal N et al. (2017) Associations of ?-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts. Blood Adv 1:693-698

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