ThepreviousthreecyclesoftheDartmouth-BostonUniversity-Muhimbili(DBM)FogartyHIVtrainingprogram haveresultedinamulti-facetedresearchandtrainingcollaborationbetweenDartmouth,BUandMuhimbili UniversityofHealthandAlliedSciences(MUHAS).Ithasproducedlandmarkstudiesontheepidemiologyof HIV,tuberculosis(TB)andHIV-relatedTB(HIV-TB),clinicalfeaturesofadultandpediatricHIV-TB,vaccine trialstopreventHIV-TB,andnutritionalsupplementationforwomenwithHIV-TB. Ourcurrent5-yearawardculminatedinMUHAS?approvalofaTBResearchInstitute(TRIM-TB),whichisan HIV-TBresearchcollaborationbetweentheDBMFogartyprogram,MUHASandtheTanzanianNational ProgrammeonTuberculosisandLeprosy(NTLP).RecognizingthebenefitsofTRIM-TB,MUHASleadership endorsedtheconceptofabroaderinitiative,designatedastheInfectiousDiseaseInstitute(IDI).Thenewly approvedIDIwillsupportresearchandtraininginallinfectiousdiseasesofimportanceinTanzania,withan initialfocusonHIVandTB.MUHAS,theNTLPandtheNationalAIDSControlProgram(NACP)havesolicited theDBMFogartyProgramtoprovidethetrainingneededtoachievetheIDI?sgoals.Tothatend,wepropose: 1)TrainIDIresearchfacultytoconductHIVandHIV/TBepidemiologicresearchandclinicaltrials 2)EstablishamentoringprogramthroughIDItoensurejuniorfacultyaresupportedandsuccessfulin performingresearchandobtainingindependentresearchfunding. 3)ExpandtheportfoliooffundedcollaborativeHIVandHIV/TBresearchforMUHASfaculty/trainees. 4)DevelopaprogramofresearchtrainingforTanzanianfieldscientistsledbyIDIfaculty Todevelopthepresentproposal,weconductedacomprehensiveneedsassessmentincluding:1)discussions withkeystakeholders/leadershipatMUHAS,NTLPandNACP,2)interviewswithkeyMUHASfaculty,and3)a surveyofDBMFogartyalumni.Inresponse,wefocusedourprogramontraininginepidemiology,biostatistics andclinicaltrials,developingstrongTanzanianmentors,expandingtheresearchportfoliousingNTLPand NACPdata,andsupportingtheIDItodevelopitspermanentresearchtrainingprogram. Attheendofthisproposedtrainingprogram,5TanzanianresearcherswillhavegraduatedwithPhDdegrees inepidemiologyand/orbiostatistics,1withaMastersdegreeinEpidemiology,and4withMastersofPublic Healthdegrees;?18willhavecompletedshortcoursetrainingoutsideofTanzaniainepidemiology,biostatistics, TB/HIV/STDresearchmethods;?andover150willhaveattendedinteractive,hands-onworkshopsinDares SalaamonHIV-TBclinicalresearch,monitoring&evaluation,dataanalysis,andgrantandmanuscriptwriting. ThistrainingprogramwillprovidetheexpertisetoestablishIDIasthepremiereself-sustainingresearchand traininginstituteforHIVandTBinEastAfrica.
OurDartmouth-BostonUniversity-Muhimbili(DBM)FogartyHIVtrainingprogramwillbuildonourpriorFogarty- supportedcapacitybuildingactivitiesandtrainresearchfacultytoconductHIVandHIV/TBepidemiologic researchandclinicaltrialsatthenewlyestablishedInfectiousDiseaseInstitute(IDI)atMuhimbiliUniversityof HealthandAlliedSciences(MUHAS).Wewillestablishacollaborativementoringprogramtoensurejunior facultyaresupportedandsuccessfulinperformingresearchandinobtainingindependentfundingaspartof IDI?sresearchtrainingprogramwhilealsoexpandingMUHAS?portfoliooffundedHIVandHIV/TBresearch. ThistrainingprogramwillprovidetheexpertisetoestablishIDIasthepremiereself-sustainingresearchand traininginstituteforHIVandTBinEastAfrica.
| Cheng, Hao D; Grimm, Sebastian K; Gilman, Morgan Sa et al. (2018) Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. JCI Insight 3: |
| Adams, Lisa V; McQuillan, Thomas; Naburi, Helga E et al. (2014) Diagnosis and treatment of tuberculosis among children at an HIV care program in Dar es Salaam, Tanzania. Pediatr Infect Dis J 33:1234-6 |
| Kim, Faith; Neke, Nyasule M; Hendricks, Kristy et al. (2014) Deficiencies of macronutrient intake among HIV-positive breastfeeding women in Dar es Salaam, Tanzania. J Acquir Immune Defic Syndr 67:569-72 |
