As dramatic as the advances in chemistry in the late 19th century and physics in the early20th century, advances in biology and medicine will characterize the early 21st century. Cellularand genetic therapies will come of age. I am applying for the Pioneer Award based on the ideathat the work I will pursue will have a major impact on the development of cellular therapies,with a particular focus on applying knowledge of adult stem cell biology to enhance tissue repairand regeneration in the elderly. The demographics of our society are compelling in terms of theextraordinary challenges that will be faced in the coming decades as the population ages and thehealth issues of individuals in their 70 s, 80 s, and 90 s become an increasingly importantchallenge to the scientific and medical communities. The long-term goal of the studies broadlyoutlined here is the restoration of tissue health and functionality to aging individuals who sufferfrom injury and disease. It is the intersection of stem cell biology, the biology of aging, andbioengineering that holds this great promise.
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