Abstract

We propose to integrate modern bioengineering techniques with psychiatry. We will launch a large-scale systematic operation, driven by modern bioengineering tools and principles, to map key neural circuit dynamics with millisecond temporal resolution. Outcomes of this work will include fundamental new conceptualizations of neuropsychiatric disease, a wealth of basic neuroscience and bioengineering insights, and potent, specific circuit-modulation interventions for treatment of neuropsychiatric disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
NIH Director’s Pioneer Award (NDPA) (DP1)
Project #
5DP1OD000616-05
Application #
7682945
Study Section
Special Emphasis Panel (ZGM1-NDPA-G (P3))
Program Officer
Jones, Warren
Project Start
2005-09-30
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2011-07-31
Support Year
5
Fiscal Year
2009
Total Cost
$761,670
Indirect Cost

  Institution

Name
Stanford University
Department
Biomedical Engineering
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Kumar, C Ranjith; Suguna, S (2016) Visual Semantic Based 3D Video Retrieval System Using HDFS. Data Min Knowl Discov 10:3806-3825
Chung, Kwanghun; Wallace, Jenelle; Kim, Sung-Yon et al. (2013) Structural and molecular interrogation of intact biological systems. Nature 497:332-7
Mei, Yuan; Zhang, Feng (2012) Molecular tools and approaches for optogenetics. Biol Psychiatry 71:1033-8
Fenno, Lief; Yizhar, Ofer; Deisseroth, Karl (2011) The development and application of optogenetics. Annu Rev Neurosci 34:389-412
Yizhar, Ofer; Fenno, Lief E; Davidson, Thomas J et al. (2011) Optogenetics in neural systems. Neuron 71:9-34
Stroh, Albrecht; Tsai, Hsing-Chen; Wang, Li-Ping et al. (2011) Tracking stem cell differentiation in the setting of automated optogenetic stimulation. Stem Cells 29:78-88
Tye, Kay M; Prakash, Rohit; Kim, Sung-Yon et al. (2011) Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature 471:358-62
Yizhar, Ofer; Fenno, Lief E; Prigge, Matthias et al. (2011) Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477:171-8
Witten, Ilana B; Steinberg, Elizabeth E; Lee, Soo Yeun et al. (2011) Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron 72:721-33
Witten, Ilana B; Lin, Shih-Chun; Brodsky, Matthew et al. (2010) Cholinergic interneurons control local circuit activity and cocaine conditioning. Science 330:1677-81

Showing the most recent 10 out of 11 publications