Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
NIH Director’s New Innovator Awards (DP2)
Project #
1DP2OD002721-01
Application #
7431988
Study Section
Special Emphasis Panel (ZGM1-NDIA-G (07))
Program Officer
Basavappa, Ravi
Project Start
2007-09-30
Project End
2009-12-31
Budget Start
2007-09-30
Budget End
2009-12-31
Support Year
1
Fiscal Year
2007
Total Cost
$822,020
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Neurology
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Martín-Peña, Alfonso; Rincón-Limas, Diego E; Fernandez-Fúnez, Pedro (2018) Engineered Hsp70 chaperones prevent A?42-induced memory impairments in a Drosophila model of Alzheimer's disease. Sci Rep 8:9915
Sanchez-Garcia, Jonatan; Fernandez-Funez, Pedro (2018) D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals. Neurobiol Dis 119:1-12
Martin-Peña, Alfonso; Rincon-Limas, Diego E; Fernandez-Funez, Pedro (2017) Anti-A? single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer's disease. Sci Rep 7:11268
Fernandez-Funez, Pedro; Sanchez-Garcia, Jonatan; de Mena, Lorena et al. (2016) Holdase activity of secreted Hsp70 masks amyloid-?42 neurotoxicity in Drosophila. Proc Natl Acad Sci U S A 113:E5212-21
Sanchez-Garcia, J; Jensen, K; Zhang, Y et al. (2016) A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila. Neurobiol Dis 95:204-9
Fernandez-Funez, Pedro; de Mena, Lorena; Rincon-Limas, Diego E (2015) Modeling the complex pathology of Alzheimer's disease in Drosophila. Exp Neurol 274:58-71
Fernandez-Funez, Pedro; Zhang, Yan; Sanchez-Garcia, Jonatan et al. (2015) Anti-A? single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease. Hum Mol Genet 24:6093-105
Zhang, Yan; Casas-Tinto, Sergio; Rincon-Limas, Diego E et al. (2014) Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila. PLoS One 9:e88522
Sanchez-Garcia, Jonatan; Arbelaez, Daniela; Jensen, Kurt et al. (2013) Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking. Hum Mol Genet 22:4253-66
Castillo-Carranza, Diana L; Zhang, Yan; Guerrero-Muñoz, Marcos J et al. (2012) Differential activation of the ER stress factor XBP1 by oligomeric assemblies. Neurochem Res 37:1707-17

Showing the most recent 10 out of 16 publications