Mechanisms of Prion Misfolding

Fernandez-Funez, Pedro

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Office of The Director, National Institutes of Health (OD)
• Type: NIH Director’s New Innovator Awards (DP2)
• Project #: 1DP2OD002721-01
• Application #: 7431988
• Study Section: Special Emphasis Panel (ZGM1-NDIA-G (07))
• Program Officer: Basavappa, Ravi
• Project Start: 2007-09-30
• Project End: 2009-12-31
• Budget Start: 2007-09-30
• Budget End: 2009-12-31
• Support Year: 1
• Fiscal Year: 2007
• Total Cost: $822,020

Institution

• Name: University of Texas Medical Br Galveston
• Department: Neurology
• Type: Schools of Medicine
• DUNS #: 800771149
• City: Galveston
• State: TX
• Country: United States
• Zip Code: 77555

Publications

Martín-Peña, Alfonso; Rincón-Limas, Diego E; Fernandez-Fúnez, Pedro (2018) Engineered Hsp70 chaperones prevent A?42-induced memory impairments in a Drosophila model of Alzheimer's disease. Sci Rep 8:9915

Sanchez-Garcia, Jonatan; Fernandez-Funez, Pedro (2018) D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals. Neurobiol Dis 119:1-12

Martin-Peña, Alfonso; Rincon-Limas, Diego E; Fernandez-Funez, Pedro (2017) Anti-A? single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer's disease. Sci Rep 7:11268

Fernandez-Funez, Pedro; Sanchez-Garcia, Jonatan; de Mena, Lorena et al. (2016) Holdase activity of secreted Hsp70 masks amyloid-?42 neurotoxicity in Drosophila. Proc Natl Acad Sci U S A 113:E5212-21

Sanchez-Garcia, J; Jensen, K; Zhang, Y et al. (2016) A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila. Neurobiol Dis 95:204-9

Fernandez-Funez, Pedro; de Mena, Lorena; Rincon-Limas, Diego E (2015) Modeling the complex pathology of Alzheimer's disease in Drosophila. Exp Neurol 274:58-71

Fernandez-Funez, Pedro; Zhang, Yan; Sanchez-Garcia, Jonatan et al. (2015) Anti-A? single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease. Hum Mol Genet 24:6093-105

Zhang, Yan; Casas-Tinto, Sergio; Rincon-Limas, Diego E et al. (2014) Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila. PLoS One 9:e88522

Sanchez-Garcia, Jonatan; Arbelaez, Daniela; Jensen, Kurt et al. (2013) Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking. Hum Mol Genet 22:4253-66

Rincon-Limas, Diego E; Jensen, Kurt; Fernandez-Funez, Pedro (2012) Drosophila models of proteinopathies: the little fly that could. Curr Pharm Des 18:1108-22