The group of Prof. Fridovich has been studying the enzymology and the physiological role of SODs as well as the mechanism of superoxide radical-induced cell damage for more than 20 years. Having the opportunity to work under his guidance I expect to become familiar with the most advanced concepts for the mechanism of superoxide toxicity. This includes the possibility for direct action of superoxide on cell constituents. I'll be able to use quite new methodological approaches such as investigations on mutants lacking protecting enzymes. Furthermore, I'll have free access to the forefront research facilities and, what is the most important, could be able to exchange ideas for new promising aspects of the biochemistry of free radicals.
| Benov, L T; Beyer Jr, W F; Stevens, R D et al. (1996) Purification and characterization of the Cu,Zn SOD from Escherichia coli. Free Radic Biol Med 21:117-21 |
| Benov, L; Chang, L Y; Day, B et al. (1995) Copper, zinc superoxide dismutase in Escherichia coli: periplasmic localization. Arch Biochem Biophys 319:508-11 |
| Benov, L; Fridovich, I (1995) A superoxide dismutase mimic protects sodA sodB Escherichia coli against aerobic heating and stationary-phase death. Arch Biochem Biophys 322:291-4 |
| Benov, L; Fridovich, I (1995) Superoxide dismutase protects against aerobic heat shock in Escherichia coli. J Bacteriol 177:3344-6 |
| Benov, L T; Fridovich, I (1994) Escherichia coli expresses a copper- and zinc-containing superoxide dismutase. J Biol Chem 269:25310-4 |
