Wound healing is an integral part of every surgical procedure, and in 1992 there were 34 million injury related visits to emergency rooms at a cost of 9.2 billion dollars in the United States alone. Stress has been shown to prolong the time course of healing and increase the risk of infection. The long-term objectives of this proposal are to elucidate the mechanisms by which stress impairs wound healing and to determine how this impairment can be ameliorated. This will be done using a well-characterized murine model of stress impaired healing that parallels stress effects seen in humans.
The specific aims are as follows: I. Determine the effects of hyperoxia on stress-impaired healing. II. Assess the role of alpha-adrenergic receptors in stress-impaired wound oxygen levels and healing. The outcomes by which these aims will be assessed include delay in closure, level of oxygenation, quantity of bacteria and neutrophils, oxygen-dependent gene expression and nitric oxide synthesis. The results of the proposed experiments will potentially be used to develop therapeutic interventions that will benefit a broad population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (ADAMHA) (F30)
Project #
5F30DE017270-05
Application #
7666161
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
Frieden, Leslie A
Project Start
2005-09-01
Project End
2010-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
5
Fiscal Year
2009
Total Cost
$69,425
Indirect Cost
Name
University of Illinois at Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612