? ? The objective of this research is to understand the intrinsic ongoing functionality of the human brain present even in the absence of tasks or stimuli. Specifically, the current study will characterize the functional relevance of intrinsic or spontaneous fluctuations in the fMRI BOLD signal. The effect of these spontaneous fluctuations on task-related BOLD responses as well as the influence of spontaneous fluctuations on behavior will be examined. Determining the relationship between spontaneous fluctuations in neural activity, the neuronal response to a stimulus, and the resulting behavior is critical to understanding the operation of the brain. Further, the functional relevance of spontaneous BOLD fluctuations is important for understanding reported disturbances in these fluctuations in different pathological conditions. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (ADAMHA) (F30)
Project #
1F30NS054398-01
Application #
7056460
Study Section
Special Emphasis Panel (ZNS1-SRB-M (24))
Program Officer
Babcock, Debra J
Project Start
2006-01-01
Project End
2009-12-31
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
1
Fiscal Year
2006
Total Cost
$26,773
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Fox, Michael D; Zhang, Dongyang; Snyder, Abraham Z et al. (2009) The global signal and observed anticorrelated resting state brain networks. J Neurophysiol 101:3270-83
Fox, Michael D; Snyder, Abraham Z; Vincent, Justin L et al. (2007) Intrinsic fluctuations within cortical systems account for intertrial variability in human behavior. Neuron 56:171-84
Fox, Michael D; Raichle, Marcus E (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700-11
Fox, Michael D; Corbetta, Maurizio; Snyder, Abraham Z et al. (2006) Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci U S A 103:10046-51