The co-use of alcohol and nicotine is positively correlated in man, with people who drink alcohol having an increased probability of smoking and vice versa. Although alcohol and nicotine are known to be one of the most common combinations of drugs abused by man, little is known about the relationship between these two drugs. The experiments proposed will examine the interaction between these drugs in rats by investigating the effect of self-administration of one drug on the subsequent self-administration of the other drug as well as the concurrent administration of both. The hypothesis being tested predicts that alcohol and nicotine are interacting by a pharmacological mechanism and that self-administration of one drug will be affected only when the other drug is present. These experiments are unique because the rats will be able to self-administer both nicotine (intravenously) and alcohol (orally) during daily operant sessions. Examination of the relationship between alcohol and nicotine using this procedure will develop a model that can be used for further determination of the mechanism of the interaction between these two drugs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31AA005566-01
Application #
6070068
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Hunt, Walter
Project Start
2000-09-01
Project End
Budget Start
2000-03-01
Budget End
2001-02-28
Support Year
1
Fiscal Year
2000
Total Cost
$31,290
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Sharpe, Amanda L; Samson, Herman H (2003) Ethanol and sucrose self-administration components: effects of drinking history. Alcohol 29:31-8
Sharpe, Amanda L; Samson, Herman H (2002) Repeated nicotine injections decrease operant ethanol self-administration. Alcohol 28:1-7
Sharpe , A L; Samson, H H (2001) Effect of naloxone on appetitive and consummatory phases of ethanol self-administration. Alcohol Clin Exp Res 25:1006-11