Abstract

Opposing ethanol self-administration behaviors are observed when comparing two strains of mice: C57BL/6Jx NZB/B1NJ F1 hybrids (B6xNZB) avoid ethanol (avoiders) after experience with high concentrations of eth-anol and C57BL/6J x FVB/NJ F1 hybrids (BGxFVB) do not (revelers). The overarching hypothesis of thisproposal is that these hybrids differ in sensitivity to the aversive, but not rewarding or anxiolytic, properties ofethanol and differential levels of FosB and AFosB in specific cell types and brain regions reflects experiencedependent differences in voluntary ethanol self-administration. Hybrid sensitivity to aversive, rewarding, andanxiolytic properties of ethanol will be determined by employing the following tests; conditioned taste aver-sion, conditioned place preference, modified two bottle choice, and elevated plus maze. To define neuro-circuits engaged by ethanol avoidance and revelry, FosB and AFosB immunoreactivity will be measured inethanol experienced hybrids. Neuronal cell types of FosB and AFosB expressing neurons will also be deter-mined. Effects of strain, dose, and quantity of FosB/AFosB positive nuclei (per brain region and cell type) willbe determined. These experiments will contribute to the understanding of alcohol use and abuse.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31AA016424-03
Application #
7535038
Study Section
Special Emphasis Panel (ZRG1-HOP-U (29))
Program Officer
Parsian, Abbas
Project Start
2006-12-01
Project End
2009-04-30
Budget Start
2008-12-01
Budget End
2009-04-30
Support Year
3
Fiscal Year
2009
Total Cost
$12,211
Indirect Cost

  Institution

Name
University of Texas Austin
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712

  Publications

Ozburn, Angela Renee; Harris, R Adron; Blednov, Yuri A (2013) Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice. Pharmacol Biochem Behav 104:33-9
Ozburn, Angela R; Mayfield, R D; Ponomarev, Igor et al. (2012) Chronic self-administration of alcohol results in elevated ?FosB: comparison of hybrid mice with distinct drinking patterns. BMC Neurosci 13:130
Ozburn, A R; Harris, R A; Blednov, Y A (2010) Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intake. Behav Genet 40:551-63
Ozburn, Angela Renee; Harris, R Adron; Blednov, Yuri A (2008) Wheel running, voluntary ethanol consumption, and hedonic substitution. Alcohol 42:417-24