Alzheimer's disease (AD) is a devastating neurodegenerative disorder that affects 5 million Americans age 65 and older, and this prevalance is expected to increase more than 50% by the year 2030. AD, therefore, is a serious and growing challenge to the health and well-being of Americans, and research must be devoted to lessening its impact. An emerging potential therapy for Alzheimer's Disease (AD) is the transplantation of stem cells, and recently our laboratory has found that implanting neural stem cells (NSC) into the hippocampus of mice with the hallmarl
Castello, Nicholas A; Nguyen, Michael H; Tran, Jenny D et al. (2014) 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. PLoS One 9:e91453 |
Castello, Nicholas A; Green, Kim N; LaFerla, Frank M (2012) Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aýý or tau pathology. PLoS One 7:e39566 |