Chronic stress-induced activation of the hypothalamus-pituitary-adrenal (HPA) axis can influence the primary immune response to a pathogen, and can have significant impact on the outcome to an infectious disease. Whether chronic stress alters the generation of the memory T cell response, and whether a secondary response to pathogen challenge is affected by priming T cells under a """"""""stressed environment"""""""" are not well established. In this proposal, we test the central hypothesis that chronic non-habituating stress induces repeated activation of the HPA axis, hindering the development and/or effector function of Listeria- specific memory CD8+ T cells. This model will yield information that reflects how physical and/or psychological stress in humans may affect immune responses to pathogens, and can impact the effectiveness of profilactic and therapeutic vaccines. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31AI071412-02
Application #
7671491
Study Section
Special Emphasis Panel (ZRG1-EMNR-E (29))
Program Officer
Adger-Johnson, Diane S
Project Start
2007-06-01
Project End
2010-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
2
Fiscal Year
2008
Total Cost
$40,972
Indirect Cost
Name
University of Rochester
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627