Keloids are benign fibrous growths caused by abnormal wound healing occurring in some individuals and their relatives. This condition is common in individuals of African and Asian descent. The precise molecular and biochemical dysfunctions that lead to keloid formation remains unknown. However, there appears to be a genetic predisposition. Given this possible genetic predisposition to keloids, I propose a positional cloning strategy to identify the genes responsible for keloids. l) Using segregation analysis in affected families, the mode of inheritance will be analyzed 2) Linkage analysis will also be used to identify the chromosomal location of the predisposing gene for the purpose of ultimately cloning and characterizing the genetic lesion. Based on research conducted at Meharry Medical College on keloids, members of the jun/fos family of transcription factors have been chosen as candidate genes for the linkage analysis. The results of this proposal should help us to understand the mechanism of wound healing in keloids.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31AR008424-02
Application #
2517413
Study Section
Special Emphasis Panel (ZRG5-MBC-1 (01))
Project Start
1997-08-08
Project End
Budget Start
1997-08-08
Budget End
1998-08-07
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Meharry Medical College
Department
Other Basic Sciences
Type
Other Domestic Higher Education
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37208