Investigating cellular response to biomaterials is of great interest, particularly the interaction with biomaterials that incorporate stimulatory cues, such as electric signals, to regulate cell functions. Biomaterials could also be engineered to respond to cellular behavior, thus potentially applicable in the development of diagnostic sensors. It has been demonstrated that biomaterial surface topography, chemical nature, and stimulatory characteristics influence cell behavior. For example, it has been shown that osteoblasts (bone-forming cells) respond to electrical stimulation as well as to substrate topography. The large variable space and complex phenomena that control materials surface features encourages the use of high-throughput methods to evaluate them. With this in mind, the overall objective of this proposal is to develop combinatorial patterned libraries of conductive polythiophene and nonconductive polystyrene as substrates for inducing attachment and proliferation in osteoblasts. The combinatorial approach will allow us to create surfaces with thousands of variations in properties allowing efficient study of the effect of polymer surface features and chemistry on cell functions. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31AR054215-02
Application #
7268852
Study Section
Special Emphasis Panel (ZRG1-GGG-G (29))
Program Officer
Wang, Fei
Project Start
2006-08-01
Project End
2008-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
2
Fiscal Year
2007
Total Cost
$42,531
Indirect Cost
Name
Georgia Institute of Technology
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
097394084
City
Atlanta
State
GA
Country
United States
Zip Code
30332
Rincon, Charlene; Chen, Chien-Chiang; Meredith, J Carson (2010) Effect of poly(3-octylthiophene) doping on the attachment and proliferation of osteoblasts. Macromol Biosci 10:1536-43
Rincon, Charlene; Meredith, J Carson (2010) Osteoblast adhesion and proliferation on poly(3-octylthiophene) thin films. Macromol Biosci 10:258-64