The research application contained herein outlines a program of study to investigate the beneficial effects of dietary blueberry supplementation on survival of transplanted neural tissues. A unique technique of intraocular transplantation will be used to assess the survival of transplanted neural tissue in a middle- aged host with and without blueberry supplementation. Preliminary data completed previously indicates that dietary blueberry supplementation improves the ability of a middle- aged host animal to support graft survival and growth. The present application focuses on two possible paradigms by which blueberry supplementation improves graft survival: reduction of factors that inhibit graft survival, and promotion of factors that support graft survival. These studies encompass training in highly specialized techniques that are necessary for a competitive career in research. In addition, these experiments focus on nutritional intervention in improving survival of transplanted neural tissue to a middle-aged host animal, a new focus in the field of aging and alternative medicine.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31AT003023-01
Application #
6994156
Study Section
Special Emphasis Panel (ZAT1-LD (01))
Program Officer
Pearson, Nancy
Project Start
2005-08-01
Project End
2008-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
1
Fiscal Year
2005
Total Cost
$32,405
Indirect Cost
Name
Medical University of South Carolina
Department
Neurosciences
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425