Cancer continues to be a nationwide concern. Despite extensive years of research in the field of tumor biology, the behavior of malignant tumors remain poorly understood. An area of increasing interest among clinicians and biotechnology scientists is the design of advanced diagnostic tools that are capable of early cancer detection and improved treatment matching. Mathematical models of tumor growth and therapy response show a promising future as innovative diagnostic tools for cancer treatment. This project will incorporate a continuum scale mathematical model to investigate and predict quantitatively the dependency of tumor-induced angiogenesis on the spatial-temporal distribution of VEGF and HIF-1 alpha tumor promoting factors, and tumor cell population in three-dimensional tumors. These objectives will be met by 1) developing a three-dimensional in-vivo tumor biological model to induce tumor growth and angiogenesis, and to generate experimental parameter values; 2) integrating experimental parameters into the computational model and simulate tumor-induced angiogenesis; 3) calibrating and optimizing the computational model to correlate simulation results with in-vivo observations. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31CA123710-01A1
Application #
7323039
Study Section
Special Emphasis Panel (ZRG1-IMM-L (29))
Program Officer
Bini, Alessandra M
Project Start
2007-09-27
Project End
2009-09-26
Budget Start
2007-09-27
Budget End
2008-09-26
Support Year
1
Fiscal Year
2007
Total Cost
$31,402
Indirect Cost
Name
University of California Irvine
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
De Magalhaes, Nzola; Liaw, Lih-Huei L; Berns, Michael (2010) An instruction on the in vivo shell-less chorioallantoic membrane 3-dimensional tumor spheroid model. Cytotechnology 62:279-83
De Magalhães, Nzola; Liaw, Lih-Huei L; Berns, Michael et al. (2010) Applications of a new In vivo tumor spheroid based shell-less chorioallantoic membrane 3-D model in bioengineering research. J Biomed Sci Eng 3:20-26